Carbonic anhydrase and bacterial metabolism: a chance for antibacterial drug discovery

C Capasso, CT Supuran - Expert Opinion on Therapeutic Patents, 2024 - Taylor & Francis
ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) play a pivotal role in the
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …

Enzyme embedded metal organic framework (enzyme–MOF): De novo approaches for immobilization

SS Nadar, L Vaidya, VK Rathod - International journal of biological …, 2020 - Elsevier
The porous material has been considered as a potential candidate for immobilizing
enzymes. Recently, metal organic framework (MOF) has been emerged as a hybrid organic …

Carbonic anhydrases: role in pH control and cancer

MY Mboge, BP Mahon, R McKenna, SC Frost - Metabolites, 2018 - mdpi.com
The pH of the tumor microenvironment drives the metastatic phenotype and
chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH …

[HTML][HTML] Carbonic anhydrase to boost CO2 sequestration: Improving carbon capture utilization and storage (CCUS)

A de Oliveira Maciel, P Christakopoulos, U Rova… - Chemosphere, 2022 - Elsevier
Abstract CO 2 Capture Utilization and Storage (CCUS) is a fundamental strategy to mitigate
climate change, and carbon sequestration, through absorption, can be one of the solutions …

[HTML][HTML] An overview of the bacterial carbonic anhydrases

CT Supuran, C Capasso - Metabolites, 2017 - mdpi.com
Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …

An overview on the recently discovered iota-carbonic anhydrases

A Nocentini, CT Supuran, C Capasso - Journal of Enzyme …, 2021 - Taylor & Francis
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) have been studied for decades and have
been classified as a superfamily of enzymes which includes, up to date, eight gene families …

Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase

A Nocentini, A Angeli, F Carta, JY Winum… - Journal of Enzyme …, 2021 - Taylor & Francis
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …

Antibacterial carbonic anhydrase inhibitors: an update on the recent literature

CT Supuran, C Capasso - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
Introduction The clinically licensed drugs used as antibiotics prevent the microbial growth
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …

Enzymes from extreme environments and their industrial applications

JA Littlechild - Frontiers in bioengineering and biotechnology, 2015 - frontiersin.org
This article will discuss the importance of specific extremophilic enzymes for applications in
industrial biotechnology. It will specifically address those enzymes that have applications in …

Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii

S Del Prete, A Nocentini, CT Supuran… - Journal of Enzyme …, 2020 - Taylor & Francis
The carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse a simple but physiologically crucial
reversible reaction, the carbon dioxide hydration with the production of bicarbonate and …