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Carbonic anhydrase and bacterial metabolism: a chance for antibacterial drug discovery
C Capasso, CT Supuran - Expert Opinion on Therapeutic Patents, 2024 - Taylor & Francis
ABSTRACT Introduction Carbonic anhydrases (CAs, EC 4.2. 1.1) play a pivotal role in the
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
regulation of carbon dioxide, bicarbonate, and hydrogen ions within bacterial cells, ensuring …
Enzyme embedded metal organic framework (enzyme–MOF): De novo approaches for immobilization
The porous material has been considered as a potential candidate for immobilizing
enzymes. Recently, metal organic framework (MOF) has been emerged as a hybrid organic …
enzymes. Recently, metal organic framework (MOF) has been emerged as a hybrid organic …
Carbonic anhydrases: role in pH control and cancer
The pH of the tumor microenvironment drives the metastatic phenotype and
chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH …
chemotherapeutic resistance of tumors. Understanding the mechanisms underlying this pH …
[HTML][HTML] Carbonic anhydrase to boost CO2 sequestration: Improving carbon capture utilization and storage (CCUS)
A de Oliveira Maciel, P Christakopoulos, U Rova… - Chemosphere, 2022 - Elsevier
Abstract CO 2 Capture Utilization and Storage (CCUS) is a fundamental strategy to mitigate
climate change, and carbon sequestration, through absorption, can be one of the solutions …
climate change, and carbon sequestration, through absorption, can be one of the solutions …
[HTML][HTML] An overview of the bacterial carbonic anhydrases
CT Supuran, C Capasso - Metabolites, 2017 - mdpi.com
Bacteria encode carbonic anhydrases (CAs, EC 4.2. 1.1) belonging to three different genetic
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …
families, the α-, β-, and γ-classes. By equilibrating CO2 and bicarbonate, these …
An overview on the recently discovered iota-carbonic anhydrases
Abstract Carbonic anhydrases (CAs, EC 4.2. 1.1) have been studied for decades and have
been classified as a superfamily of enzymes which includes, up to date, eight gene families …
been classified as a superfamily of enzymes which includes, up to date, eight gene families …
Reconsidering anion inhibitors in the general context of drug design studies of modulators of activity of the classical enzyme carbonic anhydrase
Inorganic anions inhibit the metalloenzyme carbonic anhydrase (CA, EC 4.2. 1.1) generally
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
by coordinating to the active site metal ion. Cyanate was reported as a non-coordinating CA …
Antibacterial carbonic anhydrase inhibitors: an update on the recent literature
CT Supuran, C Capasso - Expert Opinion on Therapeutic Patents, 2020 - Taylor & Francis
Introduction The clinically licensed drugs used as antibiotics prevent the microbial growth
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …
interfering with the biosynthesis of proteins, nucleic acids, microorganism wall biosynthesis …
Enzymes from extreme environments and their industrial applications
JA Littlechild - Frontiers in bioengineering and biotechnology, 2015 - frontiersin.org
This article will discuss the importance of specific extremophilic enzymes for applications in
industrial biotechnology. It will specifically address those enzymes that have applications in …
industrial biotechnology. It will specifically address those enzymes that have applications in …
Bacterial ι-carbonic anhydrase: a new active class of carbonic anhydrase identified in the genome of the Gram-negative bacterium Burkholderia territorii
S Del Prete, A Nocentini, CT Supuran… - Journal of Enzyme …, 2020 - Taylor & Francis
The carbonic anhydrases (CAs, EC 4.2. 1.1) catalyse a simple but physiologically crucial
reversible reaction, the carbon dioxide hydration with the production of bicarbonate and …
reversible reaction, the carbon dioxide hydration with the production of bicarbonate and …