Is oxytocin “nature's medicine”?

CS Carter, WM Kenkel, EL MacLean, SR Wilson… - Pharmacological …, 2020‏ - Elsevier
Oxytocin is a pleiotropic, peptide hormone with broad implications for general health,
adaptation, development, reproduction, and social behavior. Endogenous oxytocin and …

[HTML][HTML] Cellular circuits in the brain and their modulation in acute and chronic pain

R Kuner, T Kuner - Physiological reviews, 2020‏ - journals.physiology.org
Chronic, pathological pain remains a global health problem and a challenge to basic and
clinical sciences. A major obstacle to preventing, treating, or reverting chronic pain has been …

The impact of TRPV1 on cancer pathogenesis and therapy: a systematic review

L Li, C Chen, C Chiang, T **ao, Y Chen… - … journal of biological …, 2021‏ - pmc.ncbi.nlm.nih.gov
The transient receptor potential cation channel subfamily V member 1 (TRPV1) is a
transmembrane protein that can be activated by various physical and chemical stimuli and is …

[HTML][HTML] TRPV1: structure, endogenous agonists, and mechanisms

M Benítez-Angeles, SL Morales-Lázaro… - International journal of …, 2020‏ - mdpi.com
The Transient Receptor Potential Vanilloid 1 (TRPV1) channel is a polymodal protein with
functions widely linked to the generation of pain. Several agonists of exogenous and …

The role of transient receptor potential vanilloid 1 in common diseases of the digestive tract and the cardiovascular and respiratory system

Q Du, Q Liao, C Chen, X Yang, R **e, J Xu - Frontiers in Physiology, 2019‏ - frontiersin.org
Transient receptor potential vanilloid subtype 1 (TRPV1), a member of the transient receptor
potential vanilloid (TRPV) channel family, is a nonselective cation channel that is widely …

TRPM8 contributes to sex dimorphism by promoting recovery of normal sensitivity in a mouse model of chronic migraine

D Alarcón-Alarcón, D Cabañero… - Nature …, 2022‏ - nature.com
TRPA1 and TRPM8 are transient receptor potential channels expressed in trigeminal
neurons that are related to pathophysiology in migraine models. Here we use a mouse …

Piezoelectric Analgesia Blocks Cancer‐Induced Bone Pain

Y Yin, P Zhao, X Xu, B Zhou, J Chen, X Jiang… - Advanced …, 2024‏ - Wiley Online Library
The manipulation of cell surface receptors' activity will open a new frontier for drug
development and disease treatment. However, limited by the desensitization of drugs …

The psychophysiology of music-based interventions and the experience of pain

CA Arnold, MK Bagg, AR Harvey - Frontiers in Psychology, 2024‏ - frontiersin.org
In modern times there is increasing acceptance that music-based interventions are useful
aids in the clinical treatment of a range of neurological and psychiatric conditions, including …

Modulation of TRPV1 channel function by natural products in the treatment of pain

MA Abbas - Chemico-biological interactions, 2020‏ - Elsevier
The capsaicin (vanilloid) receptor, TRPV1, is a heat-activated cation channel modulated by
inflammatory mediators and contributes to acute and chronic pain. TRPV1 channel is one of …

TRPM7 is the central gatekeeper of intestinal mineral absorption essential for postnatal survival

L Mittermeier, L Demirkhanyan, B Stadlbauer… - Proceedings of the …, 2019‏ - pnas.org
Zn2+, Mg2+, and Ca2+ are essential minerals required for a plethora of metabolic processes
and signaling pathways. Different categories of cation-selective channels and transporters …