BACKGROUND Spermatogenesis generates a small and highly specialised type of cell that
is apparently incapable of transcription and translation. For many years, this dogma was …

For men struggling to conceive with their partners, diagnostic tools are limited and often
consist of only a standard semen analysis. This baseline test serves as a crude estimation of …

Background The success of early reproductive events depends on an appropriate
communication between gametes/embryos and the oviduct. Extracellular vesicles (EVs) …

Background The presence of miRNAs in human reproductive tissue is intriguing and
suggests the possibility that these important regulatory molecules play a role in reproductive …

In addition to the paternal genome, spermatozoa carry several intrinsic factors, including
organelles (eg, centrioles and mitochondria) and molecules (eg, proteins and RNAs), which …

Infertility affects approximately 10–15% of couples worldwide who are attempting to
conceive, with male infertility accounting for 50% of infertility cases. Male infertility is related …

Spermatogenesis is temperature-dependent, and the increase in testicular temperature
seriously affects mammalian spermatogenesis and semen quality. In this study, the testicular …

Small non-coding RNAs (sncRNAs), being the top regulators of gene expression, have been
thoroughly studied in various biological systems, including the testis. Research over the last …

Liquid biopsy-based biomarkers, such as microRNAs, represent valuable tools for patient
management, but often do not make it to integration in the clinic. We aim to explore issues …

Background Human semen quality has declined in industrialized countries. Pollution,
smoking, and the consumption of a Western-style diet are all hypothesized as potential …