In this Review, we highlight some recent developments in the discovery and application of
broadly neutralizing antibodies (bnAbs) to human immunodeficiency virus (HIV); ie …

HIV-1 vaccine development has been stymied by an inability to induce broadly reactive
neutralizing antibodies to the envelope (Env) trimer, the sole viral antigen on the virion …

The translation of biological glycosylation in humans to the clinical applications involves
systematic studies using homogeneous samples of oligosaccharides and glycoconjugates …

Antigenic mimicry is a fundamental tenet of structure-based vaccinology. Vaccine strategies
for the human immunodeficiency virus type 1 (HIV-1) focus on the mimicry of its envelope …

Many broadly neutralizing antibodies (bnAbs) against HIV-1 recognize and/or penetrate the
glycan shield on native, virion-associated envelope glycoprotein (Env) spikes. The same …

Structure-defined N-glycans are essential tools to uncover the molecular basis of N-glycan
functions. However, the difficulty in obtaining diverse collections of well-defined N-glycans …

The emergence of the betacoronavirus, SARS-CoV-2 that causes COVID-19, represents a
significant threat to global human health. Vaccine development is focused on the principal …

The glycocalyx is an information-dense network of biomacromolecules extensively modified
through glycosylation that populates the cellular boundary. The glycocalyx regulates …

Carbohydrate-binding antibodies play diverse and critical roles in human health.
Endogenous carbohydrate-binding antibodies that recognize bacterial, fungal, and other …

A large array of broadly neutralizing antibodies (bnAbs) against HIV have been isolated and
described, particularly in the last decade. This continually expanding array of bnAbs has …