Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …

Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …

Cellular senescence entails a permanent proliferative arrest, coupled to multiple phenotypic
changes. Among these changes is the release of numerous biologically active molecules …

One of the key issues facing public healthcare is the global trend of an increasingly ageing
society which continues to present policy makers and caregivers with formidable healthcare …

Although death is inevitable, individuals have long sought to alter the course of the ageing
process. Indeed, ageing has proved to be modifiable; by intervening in biological systems …

Background Treatment with the α-glucosidase inhibitor acarbose increases median lifespan
by approximately 20% in male mice and 5% in females. This longevity extension differs from …

The epidemic of obesity is a major challenge for health policymakers due to its far-reaching
effects on population health and potentially overwhelming financial burden on healthcare …

Common chronic diseases represent the greatest driver of rising healthcare costs, as well as
declining function, independence, and quality of life. Geroscience‐guided approaches seek …

Human longevity has increased dramatically during the past century. More than 20% of the 9
billion population of the world will exceed the age of 60 in 2050. Since the last three …

New strategies to block the immune evasion activity of programmed death ligand-1 (PD-L1)
are urgently needed. When exploring the PD-L1-targeted effects of mechanistically diverse …