Mitophagy is a selective autophagic process, essential for cellular homeostasis, that
eliminates dysfunctional mitochondria. Activated by inner membrane depolarization, it plays …

A variety of cognitive disorders are worsened by stress exposure and involve dysfunction of
the newly evolved prefrontal cortex (PFC). Exposure to acute, uncontrollable stress …

Autism Spectrum Disorders (ASD) and Schizophrenia (SCZ) are cognitive disorders with
complex genetic architectures but overlap** behavioral phenotypes, which suggests …

The prefrontal cortex (PFC)—the most evolved brain region—subserves our highest-order
cognitive abilities. However, it is also the brain region that is most sensitive to the detrimental …

Spatial working memory (WM; ie," scratchpad" memory) is constantly updated to guide
behavior based on representational knowledge of spatial position. It is maintained by …

Recent advances in our understanding of the underlying genetic architecture of psychiatric
disorders has blown away the diagnostic boundaries that are defined by currently used …

Synaptic spines are dynamic structures that regulate neuronal responsiveness and
plasticity. We examined the role of the schizophrenia risk factor DISC1 in the maintenance of …

Adult neurogenesis occurs throughout life in discrete regions of the adult mammalian brain.
Little is known about the mechanism governing the sequential developmental process that …

The DISC locus is located at the breakpoint of a balanced t (1; 11) chromosomal
translocation in a large and unique Scottish family. This translocation segregates in a highly …

Schizophrenia (SZ) is primarily an adult psychiatric disorder in which disturbances caused
by susceptibility genes and environmental insults during early neurodevelopment initiate …