Progress and emerging techniques for biomaterial-based derivation of mesenchymal stem cells (MSCs) from pluripotent stem cells (PSCs)

N Prakash, J Kim, J Jeon, S Kim, Y Arai… - Biomaterials …, 2023 - spj.science.org
The use of mesenchymal stem cells (MSCs) for clinical purposes has skyrocketed in the past
decade. Their multilineage differentiation potentials and immunomodulatory properties have …

Concise review: mesenchymal stem cells derived from human pluripotent cells, an unlimited and quality-controllable source for therapeutic applications

B Jiang, L Yan, X Wang, E Li, K Murphy, K Vaccaro… - Stem …, 2019 - academic.oup.com
Despite the long discrepancy over their definition, heterogeneity, and functions,
mesenchymal stem cells (MSCs) have proved to be a key player in tissue repair and …

E2F7− EZH2 axis regulates PTEN/AKT/mTOR signalling and glioblastoma progression

R Yang, M Wang, G Zhang, Y Bao, Y Wu, X Li… - British journal of …, 2020 - nature.com
Background E2F transcription factors are considered to be important drivers of tumour
growth. E2F7 is an atypical E2F factor, and its role in glioblastoma remains undefined …

Single-cell transcriptomic analysis reveals the cellular heterogeneity of mesenchymal stem cells

C Zhang, X Han, J Liu, L Chen, Y Lei… - Genomics …, 2022 - academic.oup.com
Ex vivo-expanded mesenchymal stem cells (MSCs) have been demonstrated to be a
heterogeneous mixture of cells exhibiting varying proliferative, multipotential, and …

MSX2 initiates and accelerates mesenchymal stem/stromal cell specification of hPSCs by regulating TWIST1 and PRAME

L Zhang, H Wang, C Liu, Q Wu, P Su, D Wu, J Guo… - Stem Cell Reports, 2018 - cell.com
The gap in knowledge of the molecular mechanisms underlying differentiation of human
pluripotent stem cells (hPSCs) into the mesenchymal cell lineages hinders the application of …

LincRNA-immunity landscape analysis identifies EPIC1 as a regulator of tumor immune evasion and immunotherapy resistance

W Guo, Y Wang, M Yang, Z Wang, Y Wang… - Science …, 2021 - science.org
Through an integrative analysis of the lincRNA expression and tumor immune response in
9,626 tumor samples across 32 cancer types, we developed a lincRNA-based immune …

PD-L1 expression levels in mesenchymal stromal cells predict their therapeutic values for autoimmune hepatitis

X Bai, T Chen, Y Li, X Ge, C Qiu, H Gou, S Wei… - Stem Cell Research & …, 2023 - Springer
Background Autoimmune hepatitis is a chronic inflammatory hepatic disorder with no
effective treatment. Mesenchymal stromal cells (MSCs) have emerged as a promising …

Inhibition of EZH2 ameliorates cartilage endplate degeneration and attenuates the progression of intervertebral disc degeneration via demethylation of Sox-9

C Jiang, Q Guo, Y **, JJ Xu, ZM Sun, DC Zhu… - …, 2019 - thelancet.com
Background Cartilaginous endplate (CEP) degeneration is considered as one of the major
causes of intervertebral disc degeneration (IVDD) which causes low back pain. Recent …

The molecular mechanisms and therapeutic potential of EZH2 in breast cancer

S Adibfar, M Elveny, HS Kashikova, MV Mikhailova… - Life sciences, 2021 - Elsevier
Due to its high occurrence and mortality rate, breast cancer has been studied from various
aspects as one of the cancer field's hot topics in the last decade. Epigenetic alterations are …

Activation of AKT induces EZH2-mediated β-catenin trimethylation in colorectal cancer

AH Ghobashi, TT Vuong, JW Kimani, CA Ladaika… - Iscience, 2023 - cell.com
Colorectal cancer (CRC) develops in part through the deregulation of different signaling
pathways, including activation of the WNT/β-catenin and PI3K/AKT pathways. Additionally …