Hyperuricemia and its related diseases: mechanisms and advances in therapy

L Du, Y Zong, H Li, Q Wang, L **e, B Yang… - … and Targeted Therapy, 2024 - nature.com
Hyperuricemia, characterized by elevated levels of serum uric acid (SUA), is linked to a
spectrum of commodities such as gout, cardiovascular diseases, renal disorders, metabolic …

A critical review on interplay between dietary fibers and gut microbiota

S Ye, BR Shah, J Li, H Liang, F Zhan, F Geng… - Trends in Food Science & …, 2022 - Elsevier
Background Dietary fibers, as mainly complex carbohydrates, offer various health benefits
via modulating gut microbiota composition and promoting short chain fatty acids (SCFAs) …

Short-chain fatty acids in diseases

D Zhang, YP Jian, YN Zhang, Y Li, LT Gu… - Cell Communication and …, 2023 - Springer
Short-chain fatty acids (SCFAs) are the main metabolites produced by bacterial fermentation
of dietary fibre in the gastrointestinal tract. The absorption of SCFAs is mediated by substrate …

Uric acid in metabolic syndrome: does uric acid have a definitive role?

S Copur, A Demiray, M Kanbay - European journal of internal medicine, 2022 - Elsevier
Increased serum uric acid (SUA) levels are commonly seen in patients with metabolic
syndrome and are widely accepted as risk factors for hypertension, gout, non-alcoholic fatty …

Inulin fructans in diet: Role in gut homeostasis, immunity, health outcomes and potential therapeutics

MM Tawfick, H **e, C Zhao, P Shao… - International Journal of …, 2022 - Elsevier
Inulin consumption in both humans and animal models is recognized for its prebiotic action
with the most consistent change that lies in enhancing the growth and functionality of …

Gut microbiota remodeling: A promising therapeutic strategy to confront hyperuricemia and gout

Z Wang, Y Li, W Liao, J Huang, Y Liu, Z Li… - Frontiers in cellular and …, 2022 - frontiersin.org
The incidence of hyperuricemia (HUA) and gout continuously increases and has become a
major public health problem. The gut microbiota, which colonizes the human intestine, has a …

Association between gut microbiota and elevated serum urate in two independent cohorts

J Wei, Y Zhang, N Dalbeth, R Terkeltaub… - Arthritis & …, 2022 - Wiley Online Library
Objective Hyperuricemia is a precursor to gout and is often present in other metabolic
diseases that are promoted by microbiome dysbiosis. We undertook this study to examine …

Lactic acid bacteria strains relieve hyperuricaemia by suppressing xanthine oxidase activity via a short-chain fatty acid-dependent mechanism

C Ni, X Li, L Wang, X Li, J Zhao, H Zhang, G Wang… - Food & Function, 2021 - pubs.rsc.org
Globally, the incidence of hyperuricaemia is steadily increasing. The evidence increasingly
suggests an association between hyperuricaemia and the gut microbiota, which may enable …

Unveiling the future of metabolic medicine: omics technologies driving personalized solutions for precision treatment of metabolic disorders

S Singh, DK Sarma, V Verma, R Nagpal… - … and Biophysical Research …, 2023 - Elsevier
Metabolic disorders are increasingly prevalent worldwide, leading to high rates of morbidity
and mortality. The variety of metabolic illnesses can be addressed through personalized …

Immunomodulatory effects of inulin and its intestinal metabolites

W Sheng, G Ji, L Zhang - Frontiers in Immunology, 2023 - frontiersin.org
“Dietary fiber”(DF) refers to a type of carbohydrate that cannot be digested fully. DF is not an
essential nutrient, but it plays an important part in enhancing digestive capacity and …