As the home of cellular genetic information, the nucleus has a critical role in determining cell
fate and function in response to various signals and stimuli. In addition to biochemical …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Cellular membranes can form two principally different involutions, which either exclude or
contain cytosol. The 'classical'budding reactions, such as those occurring during …

Micronuclei are small membrane-bounded compartments with a DNA content encapsulated
by a nuclear envelope and spatially separated from the primary nucleus. Micronuclei have …

The nuclear envelope is composed of the nuclear membranes, nuclear lamina, and nuclear
pore complexes. Laminopathies are diseases caused by mutations in genes encoding …

Chromosome-containing micronuclei are a feature of human cancer. Micronuclei arise from
chromosome mis-segregation and characterize tumors with elevated rates of chromosomal …

Micronuclei are aberrant nuclear compartments that can form as a result of chromosome mis-
segregation. Frequent loss of micronuclear envelope integrity exposes DNA to the …

The compartmentalization of eukaryotic cells, which is essential for their viability and
functions, is ensured by single or double bilayer membranes that separate the cell from the …

During cell division, remodelling of the nuclear envelope enables chromosome segregation
by the mitotic spindle. The reformation of sealed nuclei requires ESCRTs (endosomal …

Nuclear pore complexes (NPCs) are huge protein assemblies within the nuclear envelope
(NE) that serve as selective gates for macromolecular transport between nucleus and …