The unifying feature of all proteins that are transported out of the cytoplasm of gram-negative
bacteria by the general secretory pathway (GSP) is the presence of a long stretch of …

A previous report identified and classified a small family of Gram-negative bacterial drug and
heavy metal efflux permeases, now commonly referred to as the RND family (TC no. 2.6) …

About 25% to 30% of the bacterial proteins function in the cell envelope or outside of the
cell. These proteins are synthesized in the cytosol, and the vast majority is recognized as a …

Bacilli secrete numerous proteins into the environment. Many of the secretory proteins, their
export signals, and their processing steps during secretion have been characterized in …

SECGlp is essential for protein translocation across the endoplasmic reticulum membrane of
S. cerevisiae. We have found a mammalian homolog that shows more than 50% sequence …

Regulation of chromosomally determined nutrient cation and anion uptake systems shows
important similarities to regulation of plasmid-determined toxic ion resistance systems that …

Escherichia coli preprotein translocase contains a membrane‐embedded trimeric complex
of SecY, SecE and SecG (SecYEG) and the peripheral SecA protein. SecYE is the …

Most bacterial secretory proteins pass across the cytoplasmic membrane via the
translocase, which consists of a protein-conducting channel SecYEG and an ATP …

The SecA subunit of E. coli preprotein translocase promotes protein secretion during cycles
of membrane insertion and deinsertion at SecYEG. This process is regulated both by …

We show here that the rate of protein translocation in the bacterium Escherichia coli
depends on the levels of the SecD and SecF proteins in the cell. Overexpression of SecD …