The cannabinoid system and microglia in health and disease

SS Duffy, JP Hayes, NT Fiore, G Moalem-Taylor - Neuropharmacology, 2021 - Elsevier
Recent years have yielded significant advances in our understanding of microglia, the
immune cells of the central nervous system (CNS). Microglia are key players in CNS …

Effects of palmitoylethanolamide (PEA) on nociceptive, musculoskeletal and neuropathic pain: Systematic review and meta-analysis of clinical evidence

D Scuteri, F Guida, S Boccella, E Palazzo, S Maione… - Pharmaceutics, 2022 - mdpi.com
Some 30–50% of the global population and almost 20% of the European population actually
suffer from chronic pain, which presents a tremendous burden to society when this pain …

A decades-long journey of palmitoylethanolamide (PEA) for chronic neuropathic pain management: a comprehensive narrative review

G Varrassi, M Rekatsina, MLG Leoni, M Cascella… - Pain and Therapy, 2024 - Springer
Palmitoylethanolamide (PEA) has been prescribed in neuropathic pain management for
over 20 years. This study aims to summarize what has been published on the topic in the …

The endocannabinoid system in migraine: from bench to pharmacy and back

C Tassorelli, R Greco… - Current opinion in …, 2019 - journals.lww.com
The endocannabinoid system in migraine: from bench to pharma... : Current Opinion in
Neurology The endocannabinoid system in migraine: from bench to pharmacy and back …

The protective effects of pre-and post-administration of micronized palmitoylethanolamide formulation on postoperative pain in rats

R Siracusa, R Fusco, M Cordaro, AF Peritore… - International Journal of …, 2020 - mdpi.com
Background: Postoperative pain (PO) is a common form of acute pain. Inadequate PO
treatment is an important health problem, as it leads to worse outcomes, such as chronic …

Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy …

D Briskey, R Skinner, C Smith, A Rao - Pharmaceuticals, 2024 - mdpi.com
Migraines are a common neurological disorder that generally affects young to middle-aged
adults and females more than males. Various treatment options are available; however …

[HTML][HTML] Chemo-profiling by UPLC-QTOF MS analysis and in vitro assessment of Anti-inflammatory activity of Field Milkwort (Polygala arvensis Willd.)

MP Mane, RS Patil, AB Magdum, SS Kakade… - South African Journal of …, 2022 - Elsevier
P. arvensis has traditionally been used in folk herbal therapy to treat a variety of ailments.
This study looked at the phytochemical, antioxidant, and anti-inflammatory effects of P …

The Effects of Cannabinoids on Ischemic Stroke-Associated Neuroinflammation: A Systematic Review

EA Alraddadi, FF Aljuhani, GY Alsamiri… - Journal of Neuroimmune …, 2025 - Springer
Stroke represents a significant burden on global health and the economy, with high mortality
rates, disability, and recurrence. Ischemic stroke is a serious condition that occurs when a …

The Effect of Levagen+ (Palmitoylethanolamide) Supplementation on Symptoms of Allergic Rhinitis—A Double-Blind Placebo-Controlled Trial

D Briskey, P Ebelt, A Rao - Nutrients, 2023 - mdpi.com
Background: Allergic rhinitis (AR) is an inflammatory, symptomatic disorder stimulated by
antigen-specific immunoglobulin E inflammation in response to allergens. Current …

A decades-long journey of palmitoylethanolamide (PEA), as a cornerstone in chronic neuropathic pain management: a comprehensive narrative review

G Varrassi, A Paladini, C Corno, S Coaccioli, G Finco… - 2024 - preprints.org
Palmitoylethanolamide (PEA) has been prescribed for neuropathic pain for several years.
This study is mainly addressed to summarize what has been published on the topic in the …