Small molecules in the treatment of COVID-19

S Lei, X Chen, J Wu, X Duan, K Men - Signal transduction and targeted …, 2022 - nature.com
The outbreak of COVID-19 has become a global crisis, and brought severe disruptions to
societies and economies. Until now, effective therapeutics against COVID-19 are in high …

Molnupiravir and its antiviral activity against COVID-19

L Tian, Z Pang, M Li, F Lou, X An, S Zhu… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory
syndrome coronavirus 2 (SARS-CoV-2) constitutes a major worldwide public health threat …

[HTML][HTML] Natural products, alone or in combination with FDA-approved drugs, to treat COVID-19 and lung cancer

L Yang, Z Wang - Biomedicines, 2021 - mdpi.com
As a public health emergency of international concern, the highly contagious coronavirus
disease 2019 (COVID-19) pandemic has been identified as a severe threat to the lives of …

Isolation and biological activity of natural chalcones based on antibacterial mechanism classification

S Wang, C Li, L Zhang, B Sun, Y Cui, F Sang - Bioorganic & Medicinal …, 2023 - Elsevier
Bacterial infection, which is still one of the leading causes of death in humans, poses an
enormous threat to the worldwide public health system. Antibiotics are the primary …

Efficient disinfection of SARS-CoV-2-like coronavirus, pseudotyped SARS-CoV-2 and other coronaviruses using cold plasma induces spike protein damage

H Qin, H Qiu, ST He, B Hong, K Liu, F Lou, M Li… - Journal of hazardous …, 2022 - Elsevier
Abstract Coronavirus disease 2019 (COVID-19) has become a worldwide public health
emergency, and the high transmission of SARS-CoV-2 variants has raised serious concerns …

The lethal K18-hACE2 knock-in mouse model mimicking the severe pneumonia of COVID-19 is practicable for antiviral development

Z Zhang, L Zhou, Q Liu, Y Zheng, X Tan… - Emerging Microbes & …, 2024 - Taylor & Francis
Animal models of COVID-19 facilitate the development of vaccines and antivirals against
SARS-CoV-2. The efficacy of antivirals or vaccines may differ in different animal models with …

[HTML][HTML] Artesunate: A review of its therapeutic insights in respiratory diseases

J Zhang, Y Li, J Wan, M Zhang, C Li, J Lin - Phytomedicine, 2022 - Elsevier
Background Artesunate, as a semi-synthetic artemisinin derivative of sesquiterpene lactone,
is widely used in clinical antimalarial treatment due to its endoperoxide group. Recent …

Echinatin induces reactive oxygen species‐mediated apoptosis via JNK/P38 MAPK signaling pathway in colorectal cancer cells

AW Kwak, JY Lee, SO Lee, J Seo, JW Park… - Phytotherapy …, 2023 - Wiley Online Library
Colorectal cancer (CRC) is a very common and deadly cancer worldwide, and oxaliplatin is
used as first‐line chemotherapy. However, resistance usually develops, limiting treatment …

Significance of chalcone scaffolds in medicinal chemistry

R Mazumder, Ichudaule, A Ghosh, S Deb… - Topics in Current …, 2024 - Springer
Chalcone is a simple naturally occurring α, β-unsaturated ketone with biological importance,
which can also be easily synthesized in laboratories by reaction between two aromatic …

A SARS-CoV-2-related virus from Malayan pangolin causes lung infection without severe disease in human ACE2-transgenic mice

MQ Liu, HF Lin, J Li, Y Chen, Y Luo, W Zhang… - Journal of …, 2023 - journals.asm.org
ABSTRACT Coronavirus disease 2019 (COVID-19), which is caused by the novel
coronavirus severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is the most …