Neuroscientific therapies for atrial fibrillation

P Hanna, E Buch, S Stavrakis, C Meyer… - Cardiovascular …, 2021 - academic.oup.com
The cardiac autonomic nervous system (ANS) plays an integral role in normal cardiac
physiology as well as in disease states that cause cardiac arrhythmias. The cardiac ANS …

Intrinsic cardiac autonomic nervous system: what do clinical electrophysiologists need to know about the “heart brain”?

T Aksu, R Gopinathannair, D Gupta… - Journal of …, 2021 - Wiley Online Library
It is increasingly recognized that the autonomic nervous system (ANS) is a major contributor
in many cardiac arrhythmias. Cardiac ANS can be divided into extrinsic and intrinsic parts …

[HTML][HTML] Ectopy-triggering ganglionated plexuses ablation to prevent atrial fibrillation: GANGLIA-AF study

MY Kim, C Coyle, DR Tomlinson, MB Sikkel, A Sohaib… - Heart Rhythm, 2022 - Elsevier
Background The ganglionated plexuses (GPs) of the intrinsic cardiac autonomic system may
play a role in atrial fibrillation (AF). Objective We hypothesized that ablating the ectopy …

Autonomic changes are more durable after radiofrequency than pulsed electric field pulmonary vein ablation

P Stojadinović, D Wichterle, P Peichl… - Clinical …, 2022 - jacc.org
Background Pulmonary vein isolation (PVI) by radiofrequency (RF) energy is associated
with a collateral ganglionated plexi ablation. Pulsed electric field (PEF) is a nonthermal …

An audit of uncertainty in multi-scale cardiac electrophysiology models

RH Clayton, Y Aboelkassem… - … of the Royal …, 2020 - royalsocietypublishing.org
Models of electrical activation and recovery in cardiac cells and tissue have become
valuable research tools, and are beginning to be used in safety-critical applications …

Pulmonary vein isolation with adjunctive left atrial ganglionic plexus ablation for treatment of atrial fibrillation: A meta-analysis of randomized controlled trials

J Rackley, M Nudy, MD Gonzalez, G Naccarelli… - Journal of Interventional …, 2023 - Springer
Background Adjunctive ganglionic plexus (GP) ablation may increase the efficacy of
pulmonary vein isolation (PVI) for treatment of atrial fibrillation (AF). Prior meta-analyses …

[HTML][HTML] Feasibility of computed tomography-guided cardioneuroablation for atrial fibrillation

TM Markman, M Khoshknab, P Santangeli… - Clinical …, 2022 - jacc.org
The autonomic nervous system promotes initiation and maintenance of atrial fibrillation (AF).
Cardiac ganglionated plexus(GP), containing parasympathetic and sympathetic nerves, are …

Ganglionic plexus ablation: a step-by-step guide for electrophysiologists and review of modalities for neuromodulation for the management of atrial fibrillation

T Aksu, JR Skeete, HH Huang - … & Electrophysiology Review, 2023 - pmc.ncbi.nlm.nih.gov
As the most common sustained arrhythmia, AF is a complex clinical entity which remains a
difficult condition to durably treat in the majority of patients. Over the past few decades, the …

Understanding AF mechanisms through computational modelling and simulations

KN Aronis, RL Ali, JA Liang, S Zhou… - Arrhythmia & …, 2019 - pmc.ncbi.nlm.nih.gov
AF is a progressive disease of the atria, involving complex mechanisms related to its
initiation, maintenance and progression. Computational modelling provides a framework for …

Fractionation map** software to map ganglionated plexus sites during sinus rhythm

T Aksu, K Yalin… - Journal of Cardiovascular …, 2020 - Wiley Online Library
Ablation of ganglionated plexuses (GPs) is a relatively new technique in patients with
vasovagal syncope. Due to individual variation of GP settlement, reproducible GP detection …