Mycobacterium tuberculosis remains one of the most successful bacterial pathogens,
claiming over 1.3 million lives worldwide in 2013. The emergence of multidrug-resistant and …

Lipoteichoic acid (LTA) is an important cell wall polymer found in gram-positive bacteria.
Although the exact role of LTA is unknown, mutants display significant growth and …

The mycobacterial bacillus is encompassed by a remarkably elaborate cell wall structure.
The mycolyl-arabinogalactan-peptidoglycan (mAGP) complex is essential for the viability of …

Glycosyltransferases catalyze glycosidic bond formation using sugar donors containing a
nucleoside phosphate or a lipid phosphate leaving group. Only two structural folds, GT-A …

Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

Glycosylation reactions mainly catalyzed by glycosyltransferases (Gts) occur almost
everywhere in the biosphere, and always play crucial roles in vital processes. In order to …

Glycosyltransferases (GTs) catalyze the transfer of a sugar moiety from an activated donor
sugar onto saccharide and nonsaccharide acceptors. A sequence-based classification …

Large clostridial toxins (LCTs) are a family of bacterial exotoxins that infiltrate and destroy
target cells. Members of the LCT family include Clostridioides difficile toxins TcdA and TcdB …

Natural products have played a prominent role in the history of organic chemistry, and they
continue to be important as drugs, biological probes, and targets of study for synthetic and …

Asparagine-linked glycosylation is a post-translational modification of proteins containing
the conserved sequence motif Asn-X-Ser/Thr. The attachment of oligosaccharides is …