Abstract Anthracyclines Doxorubicin, Epirubicin, Daunorubicin and Idarubicin are used to
treat a variety of tumor types in the clinics, either alone or, most often, in combination …

Predictive markers are factors that are associated with upfront response or resistance to a
particular therapy. Predictive markers are important in oncology as tumors of the same tissue …

Background: Drug development in sarcoma has been hampered by the rarity and
heterogeneity of the disease and lack of predictive biomarkers to therapies. We assessed …

Patients with ependymoma exhibit a wide range of clinical outcomes that are currently
unexplained by clinical or histological factors. Little is known regarding molecular …

Recent evidence suggests that ovarian high‐grade serous carcinoma (HGSC) originates
from the epithelium of the fallopian tube. However, most mouse models are based on the …

Here we describe an update of the Therapeutic Target Database (http://bidd. nus. edu.
sg/group/ttd/ttd. asp) for better serving the bench-to-clinic communities and for enabling …

Abstract Background Topoisomerase II alpha (TOP2A) protein has been shown to be a
proliferation marker associated with tumor grade and Ki67 index. The prognostic effect of …

Background: Topoisomerase IIA (TOP2A) gene encodes DNA topoisomerase enzyme and
has been reported that TOP2A is broadly expressed in many types of cancers. Our study …

It has been over three decades since anthracyclines took their place as the standard
chemotherapy backbone for breast cancer in the curative setting. Though the efficacy of …

Abstract Background Topoisomerase I (TOPO1) and topoisomerase IIα (TOP2A) are specific
targets of multiple chemotherapy drugs. Increased expression of TOPO1 protein and …