A multi-center phase II trial evaluating the efficacy of palbociclib in combination with carboplatin for the treatment of unresectable recurrent or metastatic head and …
Background Palbociclib is a selective inhibitor of CDK4/6 approved in metastatic breast
cancer as well as evidence of activity in malignancies with CDK4-amplifications. Extensive …
cancer as well as evidence of activity in malignancies with CDK4-amplifications. Extensive …
Genetic analysis of sinonasal undifferentiated carcinoma discovers recurrent SWI/SNF alterations and a novel PGAP3-SRPK1 fusion gene
Abstract Background Sinonasal Undifferentiated Carcinoma (SNUC) is a rare and
aggressive skull base tumor with poor survival and limited treatment options. To date …
aggressive skull base tumor with poor survival and limited treatment options. To date …
Integrative sequencing discovers an ATF1-motif enriched molecular signature that differentiates hyalinizing clear cell carcinoma from mucoepidemoid carcinoma
Objectives Salivary gland tumors are comprised of a diverse group of malignancies with
widely varying prognoses. These cancers can be difficult to differentiate, especially in cases …
widely varying prognoses. These cancers can be difficult to differentiate, especially in cases …
Targeted molecular characterization of external auditory canal squamous cell carcinomas
GJ Basura, JD Smith, S Ellsperman… - Laryngoscope …, 2021 - Wiley Online Library
Hypothesis Squamous cell carcinomas (SCC) of the external auditory canal (EAC) may
harbor unique genomic alterations that may explain aggressive behavior and differentiate …
harbor unique genomic alterations that may explain aggressive behavior and differentiate …
[HTML][HTML] A Genome Wide CRISPR Profiling Approach Identifies Mechanisms of Cisplatin Resistance in Head and Neck Squamous Cell Carcinoma
Background Head and neck squamous cell carcinoma (HNSCC) is a lethal disease with
poor survival rates, especially for cancers arising in the oral cavity or larynx. Cisplatin is a …
poor survival rates, especially for cancers arising in the oral cavity or larynx. Cisplatin is a …
Molecular Analysis of Recurrent Translocations in Mucoepidermoid Carcinoma
E Gensterblum-Miller - 2023 - deepblue.lib.umich.edu
Head and neck cancers include a diverse group of malignancies, and pathogenesis is
driven by different recurring somatic mutations. In head and neck squamous cell carcinoma …
driven by different recurring somatic mutations. In head and neck squamous cell carcinoma …