As an essential micronutrient, copper is required for a wide range of physiological processes
in virtually all cell types. Because the accumulation of intracellular copper can induce …

Conventional cancer therapies suffer from severe off-target effects because most of them
target critical facets of cells that are generally shared by all rapidly proliferating cells. The …

Transition metal elements, such as copper, play diverse and pivotal roles in oncology. They
act as constituents of metalloenzymes involved in cellular metabolism, function as signaling …

Simple Summary Copper is an essential element for human life. However, its redox activity
can be detrimental for the cell that developed highly coordinated pathways to chelate and …

Reactive oxygen species (ROS) play a pivotal role in biological processes and continuous
ROS production in normal cells is controlled by the appropriate regulation between the silver …

Copper is one of the most abundant basic transition metals in the human body. It takes part
in oxygen metabolism, collagen synthesis, and skin pigmentation, maintaining the integrity …

Ferroptosis is a necrotic form of regulated cell death (RCD) mediated by phospholipid
peroxidation in association with free iron-mediated Fenton reactions. Disrupted iron …

Cellular senescence is characterised by the irreversible arrest of proliferation, a pro-
inflammatory secretory phenotype and evasion of programmed cell death mechanisms. We …

Elevated intracellular reactive oxygen species (ROS) and antioxidant defense systems have
been recognized as one of the hallmarks of cancer cells. Compared with normal cells …

Highlights•Disulfiram, an anti-alcoholism drug, was found owing anti-tumor activity.•The
combination of Disulfiram and copper greatly enhances its anti-tumor efficacy.•Disulfiram in …