Endometrial cancer is the most common gynecologic cancer in the United States, and its
incidence is rising. Although there have been significant recent advances in our …

Abstract Endometrial cancer accounts for~ 76,000 deaths among women each year
worldwide. Disease mortality and the increasing number of new diagnoses make …

Highlights•This ESMO Clinical Practice Guideline provides key recommendations for
managing endometrial cancer.•The guideline covers clinical and pathological diagnosis …

Endometrial cancer is the most common gynecological malignancy in high‐and middle‐
income countries. Although the overall prognosis is relatively good, high‐grade endometrial …

PURPOSE The randomized Adjuvant Chemoradiotherapy Versus Radiotherapy Alone in
Women With High-Risk Endometrial Cancer (PORTEC-3) trial investigated the benefit of …

STUDY QUESTION How should fertility-sparing treatment of patients with endometrial
carcinoma be performed? SUMMARY ANSWER Forty-eight recommendations were …

Background Risk-assessment of endometrial cancer (EC) is based on clinicopathological
factors and molecular subgroup. It is unclear whether adding hormone receptor expression …

Pathogenic somatic missense mutations within the DNA polymerase epsilon (POLE)
exonuclease domain define the important subtype of ultramutated tumours ('POLE …

Standard molecular classification of endometrial cancers (EC) is now endorsed by the WHO
and identifies p53-abnormal (p53abn) EC as the subgroup with the poorest prognosis and …

PURPOSE The molecular classification of endometrial cancer (EC) has proven to have
prognostic value and is predictive of response to adjuvant chemotherapy. Here, we …