Generation of nanoscopic membrane curvature for membrane trafficking
Curved membranes are key features of intracellular organelles, and their generation
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …
involves dynamic protein complexes. Here we describe the fundamental mechanisms such …
Membrane curvature as a signal to ensure robustness of diverse cellular processes
RC Cail, DG Drubin - Trends in Cell Biology, 2023 - cell.com
An increasing corpus of research has demonstrated that membrane shape, generated either
by the external environment of the cell or by intrinsic mechanisms such as cytokinesis and …
by the external environment of the cell or by intrinsic mechanisms such as cytokinesis and …
Clathrin coats partially preassemble and subsequently bend during endocytosis
Eukaryotic cells use clathrin-mediated endocytosis to take up a large range of extracellular
cargo. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …
cargo. During endocytosis, a clathrin coat forms on the plasma membrane, but it remains …
The structure and spontaneous curvature of clathrin lattices at the plasma membrane
Clathrin-mediated endocytosis is the primary pathway for receptor and cargo internalization
in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding …
in eukaryotic cells. It is characterized by a polyhedral clathrin lattice that coats budding …
Actin polymerization promotes invagination of flat clathrin-coated lattices in mammalian cells by pushing at lattice edges
C Yang, P Colosi, S Hugelier, D Zabezhinsky… - Nature …, 2022 - nature.com
Clathrin-mediated endocytosis (CME) requires energy input from actin polymerization in
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …
mechanically challenging conditions. The roles of actin in CME are poorly understood due to …
Induced nanoscale membrane curvature bypasses the essential endocytic function of clathrin
During clathrin-mediated endocytosis (CME), flat plasma membrane is remodeled to
produce nanometer-scale vesicles. The mechanisms underlying this remodeling are not …
produce nanometer-scale vesicles. The mechanisms underlying this remodeling are not …
Insights into membrane curvature sensing and membrane remodeling by intrinsically disordered proteins and protein regions
Cellular membranes are highly dynamic in shape. They can rapidly and precisely regulate
their shape to perform various cellular functions. The protein's ability to sense membrane …
their shape to perform various cellular functions. The protein's ability to sense membrane …
Recent developments in membrane curvature sensing and induction by proteins
Background Membrane-bound intracellular organelles have characteristic shapes attributed
to different local membrane curvatures, and these attributes are conserved across species …
to different local membrane curvatures, and these attributes are conserved across species …
Imaging vesicle formation dynamics supports the flexible model of clathrin-mediated endocytosis
Clathrin polymerization and changes in plasma membrane architecture are necessary steps
in forming vesicles to internalize cargo during clathrin-mediated endocytosis (CME) …
in forming vesicles to internalize cargo during clathrin-mediated endocytosis (CME) …
Recruitment of clathrin to intracellular membranes is sufficient for vesicle formation
C Küey, M Sittewelle, G Larocque… - Elife, 2022 - elifesciences.org
The formation of a clathrin-coated vesicle (CCV) is a major membrane remodeling process
that is crucial for membrane traffic in cells. Besides clathrin, these vesicles contain at least …
that is crucial for membrane traffic in cells. Besides clathrin, these vesicles contain at least …