Download: Download high-res image (36KB) Download: Download full-size image Cystic
fibrosis (CF) is a monogenic disease caused by mutations in the cystic fibrosis …

Key points• Lung hydration and mucus clearance rates are set by a balance between CFTR‐
mediated Cl− secretion and ENaC‐led Na+ absorption. In CF airways, CFTR is diminished …

The fourth subunit of the epithelial sodium channel, termed delta subunit (δ ENaC), was
cloned in human and monkey. Increasing evidence shows that this unique subunit and its …

Epithelial sodium channel (ENaC) are integral to maintaining salt and water homeostasis in
various biological tissues, including the kidney, lung, and colon. They enable the selective …

The mechanisms by which the epidermis responds to disturbances in barrier function and
restores homeostasis are unknown. With a perturbation of the epidermal barrier, water is …

Purpose The larynx is a uniquely situated organ, juxtaposed between the gastrointestinal
and respiratory tracts, and endures considerable immunological challenges while providing …

Sea anemones produce ion channels peptide toxins of pharmacological and biomedical
interest. However, peptides acting on ligand-gated ion channels, including acid-sensing ion …

Chronic pain is a major medical issue which reduces the quality of life of millions and inflicts
a significant burden on health authorities worldwide. Currently, management of chronic pain …

Hypertension represents a major public and global health problem, most of which likely can
be improved by lifestyle changes including changing dietary habits with less consumption of …

Background ASIC 1a, the predominant acid‐sensing ion channels (ASIC s), is implicated in
neurological disorders including stroke, traumatic spinal cord injury, and ALS. Potent ASIC …