Many physiologic effects of l-glutamate, the major excitatory neurotransmitter in the
mammalian central nervous system, are mediated via signaling by ionotropic glutamate …

The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

▪ Abstract Synaptic transmission is a dynamic process. Postsynaptic responses wax and
wane as presynaptic activity evolves. This prominent characteristic of chemical synaptic …

It has been 30 years since the discovery that repeated electrical stimulation of neural
pathways can lead to long-term potentiation in hippocampal slices. With its relevance to …

The precise subunit composition of synaptic ionotropic receptors in the brain is poorly
understood. This information is of particular importance with regard to AMPA-type glutamate …

The AMPA receptor (AMPAR) GluR2 subunit dictates the critical biophysical properties of the
receptor, strongly influences receptor assembly and trafficking, and plays pivotal roles in a …

A transmembrane aspartyl protease termed β-site APP cleavage enzyme 1 (BACE1) that
cleaves the amyloid-β precursor protein (APP), which is abundant in neurons, is required for …

Calcium ions play crucial signaling roles in many forms of activity-dependent synaptic
plasticity. Recent presynaptic [Ca2+] i measurements and manipulation of presynaptic …

Information processing in the brain requires multiple forms of synaptic plasticity that
converge on regulation of NMDA and AMPA-type glutamate receptors (NMDAR, AMPAR) …

Local-circuit, γ-aminobutyric acid-releasing inhibitory interneurons of the hippocampus and
cortex have traditionally been considered as the regulators of principal neuron activity—the …