Asthma and allergy are common conditions with complex etiologies involving both genetic
and environmental contributions. Recent genome‐wide association studies (GWAS) and …

Allergic rhinitis is clinically defined as a symptomatic disorder of the nose induced by an IgE-
mediated inflammation after allergen exposure of the membranes lining the nose. Symptoms …

The pathogenesis of asthma reflects, in part, the activity of T cell cytokines. Murine models
support participation of interleukin-4 (IL-4) and the IL-4 receptor in asthma. Selective …

A marked accumulation of eosinophils occurs in several important disorders, such as
allergic diseases, parasitic infections, and cancer. 1 The level of eosinophils in the body is …

Continuing Medical Education examination IL-13 is an immunoregulatory cytokine secreted
predominantly by activated TH2 cells. Over the past several years, it has become evident …

Matrix metalloproteinase (MMP)-9 (Gelatinase B, 92-kD type IV collagenase, EC 3.4. 24.35)
is an MMP that is present in low quantities in the healthy adult lung, but much more …

Asthma and asthma-related traits are complex diseases with strong genetic and
environmental components. Rapid progress in asthma genetics has led to the identification …

Fatty acid composition in membranes plays an important role in cellular processes and has
shown to be associated with the aetiology of several complex diseases in humans. We …

Asthma and atopy are complex phenotypes that are influenced by both genetic and
environmental factors. A review of nearly 500 papers on disease association studies …

Breast-feeding is the preferred method of infant nutrition for numerous reasons. However, its
role in the prevention of allergic disease remains controversial. Reasons for this controversy …