Kinetochores are large protein assemblies that connect chromosomes to microtubules of the
mitotic and meiotic spindles in order to distribute the replicated genome from a mother cell to …

Since discovery of the centromere-specific histone H3 variant CENP-A, centromeres have
come to be defined as chromatin structures that establish the assembly site for the complex …

Information encoded in DNA is interpreted, modified, and propagated as chromatin. The
diversity of inputs encountered by eukaryotic genomes demands a matching capacity for …

Centromeres are essential for ensuring proper chromosome segregation in eukaryotes.
Their definition relies on the presence of a centromere-specific H3 histone variant CenH3 …

The centromere is the chromosomal locus that ensures fidelity in genome transmission at
cell division. Centromere protein A (CENP-A) is a histone H3 variant that specifies …

Histones are fundamental structural components of chromatin. Eukaryotic DNA is wound
around an octamer of the core histones H2A, H2B, H3, and H4. Binding of linker histone H1 …

Centromeric chromatin undergoes major changes in composition and architecture during
each cell cycle. These changes in specialized chromatin facilitate kinetochore formation in …

Faithful chromosome segregation is essential for the maintenance of genomic integrity and
requires functional centromeres. Centromeres are epigenetically defined by the histone H3 …

Centromeres are specified epigenetically by the incorporation of the histone H3 variant
CENP-A. In humans, amphibians, and fungi, CENP-A is deposited at centromeres by the …

A fundamental challenge for the survival of all organisms is maintaining the integrity of the
genome in all cells. Cells must therefore segregate their replicated genome equally during …