Drug-resistant tuberculosis (DR-TB) threatens to derail tuberculosis control efforts,
particularly in Africa where the disease remains out of control. The dogma that DR-TB …

The monitoring of antibiotic resistance genes (ARGs) is crucial for understanding the level of
antimicrobial resistance and the associated health burden, which in turn is essential for the …

Host-directed therapies aiming to strengthen the body's immune system, represent an
underexplored opportunity to improve treatment of tuberculosis (TB). We have previously …

Background The broad use of bedaquiline and pretomanid as the mainstay of new regimens
to combat tuberculosis is a risk due to increasing bedaquiline resistance. We aimed to …

Bedaquiline is currently a key drug for treating multidrug-resistant or rifampin-resistant
tuberculosis. We report and discuss the unusual development of resistance to bedaquiline in …

This report documents the case of a Ukrainian patient infected with an extensively drug-
resistant (XDR) lineage 2 Mycobacterium tuberculosis strain harbouring the rifampicin …

We investigated the performance of the targeted next-generation sequencing (tNGS)-based
Oxford Nanopore Diagnostics AmPORE TB assay, recently approved by the World Health …

Bedaquiline resistance is increasingly observed in the treatment of rifampicin-resistant
tuberculosis (TB), yet standardized regimens for managing bedaquiline-resistant TB are …

Tuberculosis has remained one of the world's deadliest infectious diseases. The complexity
and numerous adverse effects of current treatment options as well as the emergence of multi …

Tuberculosis drug development has stagnated for decades, so the recent availability of
bedaquiline is welcome. Bedaquiline-containing regimens, now the first-line therapy …