Influenza virus and SARS-CoV-2: pathogenesis and host responses in the respiratory tract

T Flerlage, DF Boyd, V Meliopoulos… - Nature Reviews …, 2021 - nature.com
Influenza viruses cause annual epidemics and occasional pandemics of respiratory tract
infections that produce a wide spectrum of clinical disease severity in humans. The novel …

[HTML][HTML] SARS-CoV-2 in wastewater: State of the knowledge and research needs

M Kitajima, W Ahmed, K Bibby, A Carducci… - Science of The Total …, 2020 - Elsevier
The ongoing global pandemic of coronavirus disease 2019 (COVID-19) caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a Public Health …

SARS-CoV-2 viral load is associated with increased disease severity and mortality

J Fajnzylber, J Regan, K Coxen, H Corry… - Nature …, 2020 - nature.com
The relationship between SARS-CoV-2 viral load and risk of disease progression remains
largely undefined in coronavirus disease 2019 (COVID-19). Here, we quantify SARS-CoV-2 …

A narrative systematic review of the clinical utility of cycle threshold values in the context of COVID-19

SN Rao, D Manissero, VR Steele, J Pareja - Infectious diseases and …, 2020 - Springer
Background The ability to predict likely prognosis and infectiousness for patients with COVID-
19 would aid patient management decisions. Diagnosis is usually via real-time PCR, and it …

Effect of dexamethasone in hospitalized patients with COVID-19–preliminary report

P Horby, WS Lim, J Emberson, M Mafham, J Bell… - MedRxiv, 2020 - medrxiv.org
ABSTRACT Background Coronavirus disease 2019 (COVID-19) is associated with diffuse
lung damage. Corticosteroids may modulate immune-mediated lung injury and reducing …

Dexamethasone in hospitalized patients with Covid-19

RECOVERY Collaborative Group - New England Journal of …, 2021 - Mass Medical Soc
Abstract Background Coronavirus disease 2019 (Covid-19) is associated with diffuse lung
damage. Glucocorticoids may modulate inflammation-mediated lung injury and thereby …

Viral dynamics and real-time RT-PCR Ct values correlation with disease severity in COVID-19

AA Rabaan, R Tirupathi, AA Sule, J Aldali, AA Mutair… - Diagnostics, 2021 - mdpi.com
Real-time RT-PCR is considered the gold standard confirmatory test for coronavirus disease
2019 (COVID-19). However, many scientists disagree, and it is essential to understand that …

[HTML][HTML] Clinical practice guidelines by the Infectious Diseases Society of America: 2018 update on diagnosis, treatment, chemoprophylaxis, and institutional outbreak …

TM Uyeki, HH Bernstein, JS Bradley… - Clinical Infectious …, 2019 - academic.oup.com
These clinical practice guidelines are an update of the guidelines published by the
Infectious Diseases Society of America (IDSA) in 2009, prior to the 2009 H1N1 influenza …

Global initiative for the diagnosis, management, and prevention of chronic obstructive lung disease. The 2020 GOLD science committee report on COVID-19 and …

DMG Halpin, GJ Criner, A Papi, D Singh… - American journal of …, 2021 - atsjournals.org
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has raised
many questions about the management of patients with chronic obstructive pulmonary …

[HTML][HTML] Baloxavir marboxil for uncomplicated influenza in adults and adolescents

FG Hayden, N Sugaya, N Hirotsu, N Lee… - … England Journal of …, 2018 - Mass Medical Soc
Background Baloxavir marboxil is a selective inhibitor of influenza cap-dependent
endonuclease. It has shown therapeutic activity in preclinical models of influenza A and B …