[HTML][HTML] Benzimidazole and its derivatives as cancer therapeutics: The potential role from traditional to precision medicine

YT Lee, YJ Tan, CE Oon - Acta Pharmaceutica Sinica B, 2023 - Elsevier
Cancer is the second leading cause of mortality globally which remains a continuing threat
to human health today. Drug insensitivity and resistance are critical hurdles in cancer …

Imidazoles as potential anticancer agents

I Ali, MN Lone, HY Aboul-Enein - MedChemComm, 2017 - pubs.rsc.org
Cancer is a black spot on the face of humanity in this era of science and technology.
Presently, several classes of anticancer drugs are available in the market, but issues such …

Design, synthesis, molecular docking, and anticancer activity of benzoxazole derivatives as VEGFR‐2 inhibitors

AGA El‐Helby, H Sakr, IH Eissa… - Archiv der …, 2019 - Wiley Online Library
Novel series of benzoxazoles 4a‐f‐16 were designed, synthesized, and evaluated for
anticancer activity against HepG2, HCT‐116, and MCF‐7 cells. HCT‐116 was the most …

Ligand-free copper-catalyzed synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-aminobenzothiazoles, and benzoxazoles

P Saha, T Ramana, N Purkait, MA Ali… - The Journal of …, 2009 - ACS Publications
The synthesis of substituted benzimidazoles, 2-aminobenzimidazoles, 2-
aminobenzothiazoles, and benzoxazoles is described via intramolecular cyclization of o …

Transition‐metal‐catalyzed aminations and aziridinations of C H and C C bonds with iminoiodinanes

JWW Chang, TMU Ton, PWH Chan - The Chemical Record, 2011 - Wiley Online Library
Catalytic insertion or addition of a metal‐imido/nitrene species, generated from reaction of a
transition‐metal catalyst with iminoiodanes, to C H and C C bonds offers a convenient …

Design, synthesis and biological evaluation of some novel benzothiazole/benzoxazole and/or benzimidazole derivatives incorporating a pyrazole scaffold as …

MA Abdelgawad, RB Bakr, HA Omar - Bioorganic chemistry, 2017 - Elsevier
In an aim at develo** new antiproliferative agents, new series of benzothiazole/
benzoxazole and/or benzimidazole substituted pyrazole derivatives 11a-c, 12a-c and 13a-c …

Iron-Catalyzed Intramolecular O-Arylation: Synthesis of 2-Aryl Benzoxazoles

J Bonnamour, C Bolm - Organic Letters, 2008 - ACS Publications
A practical iron-catalyzed intramolecular O-arylation reaction and its application in the
synthesis of benzoxazole derivatives, starting from the readily available 2-haloanilines, is …

Benzoxazole/benzothiazole‐derived VEGFR‐2 inhibitors: design, synthesis, molecular docking, and anticancer evaluations

AGA El‐Helby, H Sakr, IH Eissa… - Archiv der …, 2019 - Wiley Online Library
A novel series of benzoxazole/benzothiazole derivatives 4a–c–11a–e were designed,
synthesized, and evaluated for anticancer activity against HepG2, HCT‐116, and MCF‐7 …

Cobalt-catalyzed intramolecular C–N and C–O cross-coupling reactions: synthesis of benzimidazoles and benzoxazoles

P Saha, MA Ali, P Ghosh… - Organic & Biomolecular …, 2010 - pubs.rsc.org
Cobalt (II)-complex catalyzes efficiently the intramolecular C–N and C–O cross-couplings of
ZN′-(2-halophenyl)-N-phenylamidines and N-(2-bromophenyl) benzamides to afford the …

Copper-Mediated Synthesis of Substituted 2-Aryl-N-benzylbenzimidazoles and 2-Arylbenzoxazoles via C–H Functionalization/C–N/C–O Bond Formation

MM Guru, MA Ali, T Punniyamurthy - The Journal of Organic …, 2011 - ACS Publications
An efficient method for the transformation of N-benzyl bisarylhydrazones and bisaryloxime
ethers to functionalized 2-aryl-N-benzylbenzimidazoles and 2-arylbenzoxazoles is …