Abstract Glycogen Synthase Kinase-3 (GSK3 or GSK-3) is a promiscuous protein kinase and
its phosphorylation of its diverse substrates has major influences on many areas of …

Protein phosphorylation is a major regulator of protein function and biological outcomes.
This was first recognized through functional biochemical experiments, and in the past …

Lysine acetylation is a conserved protein post-translational modification that links acetyl-
coenzyme A metabolism and cellular signalling. Recent advances in the identification and …

Protein post‐translational modifications (PTM s) allow the cell to regulate protein activity and
play a crucial role in the response to changes in external conditions or internal states …

The Phospho. ELM resource (http://phospho. elm. eu. org) is a relational database designed
to store in vivo and in vitro phosphorylation data extracted from the scientific literature and …

Kinases determine the phenotypes of many cancer cells, but the frequency with which
individual kinases are activated in primary tumors remains largely unknown. We used a …

Protein phosphorylation is the most common reversible post-translational modification in
eukaryotes. Humans have over 500 protein kinases, of which more than a dozen are …

Protein function is often regulated by posttranslational modifications (PTMs), and recent
advances in mass spectrometry have resulted in an exponential increase in PTM …

Protein and genetic interaction maps can reveal the overall physical and functional
landscape of a biological system. To date, these interaction maps have typically been …

Signalling networks regulate essentially all of the biology of cells and organisms in normal
and disease states. Signalling is often studied using antibody-based techniques such as …