[HTML][HTML] Steroidal saponins: naturally occurring compounds as inhibitors of the hallmarks of cancer

S Bouabdallah, A Al-Maktoum, A Amin - Cancers, 2023 - mdpi.com
Cancer is a global health burden responsible for an exponentially growing number of
incidences and mortalities, regardless of the significant advances in its treatment. The …

Natural products targeting the MAPK-signaling pathway in cancer: overview

A Shi, L Liu, S Li, B Qi - Journal of Cancer Research and Clinical …, 2024 - Springer
Purpose This article summarizes natural products that target the MAPK-signaling pathway in
cancer therapy. The classification, chemical structures, and anti-cancer mechanisms of …

Regulation of bone homeostasis by traditional Chinese medicine active scaffolds and enhancement for the osteoporosis bone regeneration

X Wang, P Tang, K Yang, S Guo, Y Tang… - Journal of …, 2024 - Elsevier
Ethnopharmacological relevance The active ingredients of traditional Chinese medicine
(TCM), such as naringin (NG), Eucommiol, isopsoralen, icariin, Astragalus polysaccharides …

Fight for Cancer Diseases using Natural Compounds and Their Semisynthetic Derivatives

YS Kurniawan, K Gurning, I Iksen… - …, 2024 - journal.pandawainstitute.com
Cancer stands as one of the deadliest diseases afflicting contemporary human societies,
encompassing over 100 distinct forms, including oral, salivary glands, oropharynx …

Genome-wide methylation, transcriptome and characteristic metabolites reveal the balance between diosgenin and brassinosteroids in Dioscorea zingiberensis

Z Li, Y Li, L Geng, J Wang, Y Ouyang… - Horticulture Research, 2024 - academic.oup.com
Diosgenin (DG) is a bioactive metabolite isolated from Dioscorea species, renowned for its
medicinal properties. Brassinosteroids (BRs) are a class of crucial plant steroidal hormones …

Redefining the significance of quinoline containing compounds as potent VEGFR-2 inhibitors for cancer therapy

J Reang, V Sharma, V Yadav, RK Tonk… - Medicinal Chemistry …, 2024 - Springer
Vascular endothelial growth factor receptor-2 (VEGFR-2), a tyrosine kinase receptor (TKR) is
frequently overexpressed in most of the cancers. It plays a crucial part in tumor angiogenesis …

Natural sapogenins as potential inhibitors of aquaporins for targeted cancer therapy: computational insights into binding and inhibition mechanism

MO Alotaibi, NM Alotaibi, MA Alwaili… - Journal of …, 2023 - Taylor & Francis
Aquaporins (AQPs) are membrane proteins that facilitate the transport of water and other
small molecules across biological membranes. AQPs are involved in various physiological …

Plant-Based Oil-in-Water Food Emulsions: Exploring the Influence of Different Formulations on Their Physicochemical Properties

C Quezada, M Urra, C Mella, RN Zúñiga, E Troncoso - Foods, 2024 - mdpi.com
The global focus on incorporating natural ingredients into the diet for health improvement
encompasses ω-3 polyunsaturated fatty acids (PUFAs) derived from plant sources, such as …

Rice bran as a potent ingredient: Unveiling its potential for value-added applications

ME Ronie, H Mamat, AHA Aziz, MS Sarjadi… - Food Science and …, 2024 - Springer
Rice bran production significantly contributes to global environmental deterioration, yet its
potential remains underutilized. This review discusses the nutritional composition, bioactive …

Phytosome-Enhanced Secondary Metabolites for Improved Anticancer Efficacy: Mechanisms and Bioavailability Review

L Mardiana, T Milanda, YE Hadisaputri… - Drug Design …, 2025 - Taylor & Francis
Purpose Phytosome technology, an advanced lipid-based delivery system, offers a
promising solution for enhancing the bioavailability and therapeutic efficacy of secondary …