Dysfunction of ABC transporters at the surface of BBB: potential implications in intractable epilepsy and applications of nanotechnology enabled drug delivery

R Mohi-ud-Din, RH Mir, PA Mir, N Banday… - Current Drug …, 2022 - benthamdirect.com
Epilepsy is a chronic neurological disorder affecting 70 million people globally. One of the
fascinating attributes of brain microvasculature is the (BBB), which controls a chain of distinct …

Machine Learning for epilepsy: a comprehensive exploration of novel EEG and MRI techniques for seizure diagnosis

N Rehab, Y Siwar, Z Mourad - Journal of Medical and Biological …, 2024 - Springer
Purpose This work focuses on automated epileptic seizure diagnosis (ESD) and prediction
(ESP) to clarify the expanding role of machine learning (ML) in epileptic analysis. It outlines …

ABCB1 Polymorphisms and Drug‐Resistant Epilepsy in a Tunisian Population

M Chouchi, H Klaa, I Ben-Youssef Turki… - Disease …, 2019 - Wiley Online Library
Background. Epilepsy is one of the most common neurological disorders with about 30%
treatment failure rate. An interindividual variations in efficacy of antiepileptic drugs (AEDs) …

Develo** a gene panel for pharmacoresistant epilepsy: a review of epilepsy pharmacogenetics

AJ Rodriguez-Acevedo, LG Gordon, N Waddell… - …, 2021 - Taylor & Francis
Evaluating genes involved in the pharmacodynamics and pharmacokinetics of epilepsy
drugs is critical to better understand pharmacoresistant epilepsy. We reviewed the …

Bayesian non-homogeneous hidden Markov model with variable selection for investigating drivers of seizure risk cycling

ET Wang, S Chiang, Z Haneef, VR Rao… - The annals of …, 2023 - pmc.ncbi.nlm.nih.gov
A major issue in the clinical management of epilepsy is the unpredictability of seizures. Yet,
traditional approaches to seizure forecasting and risk assessment in epilepsy rely heavily on …

Multi‐omic strategies applied to the study of pharmacoresistance in mesial temporal lobe epilepsy

EM Bruxel, AM do Canto, DCF Bruno… - Epilepsia …, 2022 - Wiley Online Library
Mesial temporal lobe epilepsy (MTLE) is the most common type of focal epilepsy in adults,
and hippocampal sclerosis (HS) is a frequent histopathological feature in patients with …

Biochemical aspects and therapeutic mechanisms of cannabidiol in epilepsy

APA Boleti, BEF Frihling, PS e Silva… - Neuroscience & …, 2022 - Elsevier
Epilepsy is a chronic neurological disease characterized by recurrent epileptic seizures.
Studies have shown the complexity of epileptogenesis and ictogenesis, in which …

Models for predicting treatment efficacy of antiepileptic drugs and prognosis of treatment withdrawal in epilepsy patients

S Yang, B Wang, X Han - Acta Epileptologica, 2021 - Springer
Although antiepileptic drugs (AEDs) are the most effective treatment for epilepsy, 30–40% of
patients with epilepsy would develop drug-refractory epilepsy. An accurate, preliminary …

Impact of ABCB1 polymorphism on levetiracetam serum concentrations in epileptic Uygur children in China

T Zhao, J Yu, TT Wang, J Feng, WB Zhao… - Therapeutic Drug …, 2020 - journals.lww.com
Background: Interindividual variations in the efficacy of antiseizure medications make
epilepsy treatment challenging. This is due to genetic factors such as gene polymorphisms …

The Anticonvulsant Effect of Hydroethanolic Leaf Extract of Calotropis procera (Ait) R. Br. (Apocynaceae)

E Obese, RP Biney, IT Henneh, EA Adakudugu… - Neural …, 2021 - Wiley Online Library
A number of currently used drugs have been obtained from medicinal plants which are a
major source of drugs. These drugs are either used in their pure form or modified to a …