Functional consequences of neuropeptide and small-molecule co-transmission

MP Nusbaum, DM Blitz, E Marder - Nature Reviews Neuroscience, 2017‏ - nature.com
Colocalization of small-molecule and neuropeptide transmitters is common throughout the
nervous system of all animals. The resulting co-transmission, which provides conjoint …

Dual-transmitter neurons: functional implications of co-release and co-transmission

CE Vaaga, M Borisovska, GL Westbrook - Current opinion in neurobiology, 2014‏ - Elsevier
Highlights•Co-release and co-transmission are distinct, separate modes of release.•There
are multiple classes of dual-transmitter neurons.•The consequence of co-release extends …

General principles of neuronal co-transmission: insights from multiple model systems

E Svensson, J Apergis-Schoute, G Burnstock… - Frontiers in neural …, 2019‏ - frontiersin.org
It is now accepted that neurons contain and release multiple transmitter substances.
However, we still have only limited insight into the regulation and functional effects of this co …

Beyond the wiring diagram: signalling through complex neuromodulator networks

V Brezina - … Transactions of the Royal Society B …, 2010‏ - royalsocietypublishing.org
During the computations performed by the nervous system, its 'wiring diagram'—the map of
its neurons and synaptic connections—is dynamically modified and supplemented by …

Complicating connectomes: electrical coupling creates parallel pathways and degenerate circuit mechanisms

E Marder, GJ Gutierrez… - Developmental …, 2017‏ - Wiley Online Library
Electrical coupling in circuits can produce non‐intuitive circuit dynamics, as seen in both
experimental work from the crustacean stomatogastric ganglion and in computational …

Neuropeptide modulation of microcircuits

MP Nusbaum, DM Blitz - Current opinion in neurobiology, 2012‏ - Elsevier
Neuropeptides provide functional flexibility to microcircuits, their inputs and effectors by
modulating presynaptic and postsynaptic properties and intrinsic currents. Recent studies …

Perturbation-specific responses by two neural circuits generating similar activity patterns

DJ Powell, E Marder, MP Nusbaum - Current Biology, 2021‏ - cell.com
A fundamental question in neuroscience is whether neuronal circuits with variable circuit
parameters that produce similar outputs respond comparably to equivalent perturbations. 1 …

Neural circuit regulation by identified modulatory projection neurons

DM Blitz - Frontiers in Neuroscience, 2023‏ - frontiersin.org
Rhythmic behaviors (eg, walking, breathing, and chewing) are produced by central pattern
generator (CPG) circuits. These circuits are highly dynamic due to a multitude of input they …

Neural circuit flexibility in a small sensorimotor system

DM Blitz, MP Nusbaum - Current opinion in neurobiology, 2011‏ - Elsevier
Neuronal circuits underlying rhythmic behaviors (central pattern generators: CPGs) can
generate rhythmic motor output without sensory input. However, sensory input is pivotal for …

Convergent rhythm generation from divergent cellular mechanisms

JC Rodriguez, DM Blitz, MP Nusbaum - Journal of Neuroscience, 2013‏ - jneurosci.org
Different modulatory inputs commonly elicit distinct rhythmic motor patterns from a central
pattern generator (CPG), but they can instead elicit the same pattern. We are determining …