Myocardial fibrosis, the expansion of the cardiac interstitium through deposition of
extracellular matrix proteins, is a common pathophysiologic companion of many different …

COVID-19 mortality is strongly associated with the development of severe pneumonia and
acute respiratory distress syndrome with the worst outcome resulting in cytokine release …

The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …

The study of inflammation in fear-and anxiety-based disorders has gained interest as
growing literature indicates that pro-inflammatory markers can directly modulate affective …

Stem cell-derived exosomes have recently been regarded as potential drugs for treating
spinal cord injury (SCI) by reducing reactive oxygen species (ROS) and suppressing M1 …

The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes,
endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated …

Cardiac fibroblasts are the most prevalent cell type in the heart and play a key role in
regulating normal myocardial function and in the adverse myocardial remodeling that occurs …

The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

NADPH oxidase (Nox) has a dedicated function of generating reactive oxygen species
(ROS). Accumulating evidence suggests that Nox has an important role in signal …

The field of cardiac tissue engineering has made significant strides over the last few
decades, highlighted by the development of human cell derived constructs that have shown …