At each of the brain's vast number of synapses, the presynaptic nerve terminal, synaptic cleft,
and postsynaptic specialization form a transcellular unit to enable efficient transmission of …

The postsynaptic density (PSD) is a massive protein complex, critical for synaptic strength
and plasticity in excitatory neurons. Here, the scaffolding protein PSD-95 plays a crucial role …

Beta-amyloid (Aβ) depresses excitatory synapses by a poorly understood mechanism
requiring NMDA receptor (NMDAR) function. Here, we show that increased PSD-95, a major …

Glutamate receptors are the most abundant excitatory neurotransmitter receptors in the
brain, responsible for mediating the vast majority of excitatory transmission in neuronal …

To correctly transfer information, neuronal networks need to continuously adjust their
synaptic strength to extrinsic stimuli. This ability, termed synaptic plasticity, is at the heart of …

Post-translational attachment of lipids to proteins is found in all organisms, and is important
for many biological processes. Acylation with myristic and palmitic acids are among the most …

Many postsynaptic proteins undergo palmitoylation, the reversible attachment of the fatty
acid palmitate to cysteine residues, which influences trafficking, localization, and protein …

Palmitoylation, a lipid-based posttranslational protein modification, plays a crucial role in
regulating various aspects of neuronal function through altering protein membrane …

Polyunsaturated free fatty acids (FFAs) such as arachidonic acid, released by
phospholipase activity on membrane phospholipids, have long been considered beneficial …

Dysfunction of glutamatergic synaptic plasticity in basolateral amygdala (BLA) constitutes a
critical pathogenic mechanism underlying the depression-like behaviors induced by chronic …