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Pancreatic nerves undergo prominent alterations during the evolution and progression of
human chronic pancreatitis and pancreatic cancer. Intrapancreatic nerves increase in size …

Pain models in animals have shown low predictivity for analgesic efficacy in humans, and
clinical studies are often very confounded, blurring the evaluation. Human experimental pain …

Opioids were one of the earliest classes of medications used for pain across a variety of
conditions, but morbidity and mortality have been increasingly associated with their chronic …

Visceral pain is a global term used to describe pain originating from the internal organs,
which is distinct from somatic pain. It is a hallmark of functional gastrointestinal disorders …

Background A major problem in pain medicine is the lack of knowledge about which
treatment suits a specific patient. We tested the ability of quantitative sensory testing to …

Chronic pancreatitis is typically a painful condition and it can be associated with a severe
burden of disease. The pathogenesis of pain in this disorder is poorly understood and its …

Background Intense abdominal pain is the dominant feature of chronic pancreatitis. During
the disease changes in central pain processing, eg central sensitization manifest as …

Background Chronic pancreatitis (CP) is a progressive, fibro-inflammatory disease
characterized by enzymatic autoactivation and subsequent fibrotic replacement of acinar …

To assess centrally mediated analgesic mechanisms in clinical trials with pain patients,
objective standardized methods such as electroencephalography (EEG) has many …