Overcoming barriers to patient adherence: the case for develo** innovative drug delivery systems

TH Baryakova, BH Pogostin, R Langer… - Nature Reviews Drug …, 2023‏ - nature.com
Poor medication adherence is a pervasive issue with considerable health and
socioeconomic consequences. Although the underlying reasons are generally understood …

[HTML][HTML] Alginate as a promising biopolymer in drug delivery and wound healing: A review of the state-of-the-art

MAS Abourehab, RR Rajendran, A Singh… - International Journal of …, 2022‏ - mdpi.com
Biopolymeric nanoparticulate systems hold favorable carrier properties for active delivery.
The enhancement in the research interest in alginate formulations in biomedical and …

Intranasal drug delivery: opportunities and toxicologic challenges during drug development

LA Keller, O Merkel, A Popp - Drug delivery and translational research, 2022‏ - Springer
Over the past 10 years, the interest in intranasal drug delivery in pharmaceutical R&D has
increased. This review article summarises information on intranasal administration for local …

[HTML][HTML] Nanostructured lipid carriers for site-specific drug delivery

A Khosa, S Reddi, RN Saha - Biomedicine & Pharmacotherapy, 2018‏ - Elsevier
Nanostructured lipid carriers (NLC), comprises of a blend of solid and liquid lipids which
results in a partially crystallized lipid system and imparts many advantages over solid lipid …

Nose-to-brain drug delivery: An update on clinical challenges and progress towards approval of anti-Alzheimer drugs

M Agrawal, S Saraf, S Saraf, SG Antimisiaris… - Journal of controlled …, 2018‏ - Elsevier
Abstract According to the Alzheimer Association Report (2017), Alzheimer's disease (AD) is
the 6th primary cause of death in the USA, which affects nearly 5.5 million people. In the …

Recent advances in intranasal liposomes for drug, gene, and vaccine delivery

VA Duong, TTL Nguyen, HJ Maeng - Pharmaceutics, 2023‏ - mdpi.com
Liposomes are safe, biocompatible, and biodegradable spherical nanosized vesicles
produced from cholesterol and phospholipids. Recently, liposomes have been widely …

[HTML][HTML] Recent advances in the development of in situ gelling drug delivery systems for non-parenteral administration routes

B Vigani, S Rossi, G Sandri, MC Bonferoni… - Pharmaceutics, 2020‏ - mdpi.com
In situ gelling drug delivery systems have gained enormous attention over the last decade.
They are in a sol-state before administration, and they are capable of forming gels in …

Research progress in brain-targeted nasal drug delivery

Q Huang, X Chen, S Yu, G Gong, H Shu - Frontiers in Aging …, 2024‏ - frontiersin.org
The unique anatomical and physiological connections between the nasal cavity and brain
provide a pathway for bypassing the blood–brain barrier to allow for direct brain-targeted …

Current state and future directions of intranasal delivery route for central nervous system disorders: a scientometric and visualization analysis

H Wu, Y Zhou, Y Wang, L Tong, F Wang… - Frontiers in …, 2021‏ - frontiersin.org
Background: The management of various central nervous system (CNS) disorders has been
challenging, due to highly compact blood-brain barrier (BBB) impedes the access of most …

Nasal route for vaccine and drug delivery: Features and current opportunities

YL Mato - International journal of pharmaceutics, 2019‏ - Elsevier
Mucosal administration, and specifically nasal route, constitutes an alternative and
promising strategy for drug and vaccine delivery. Mucosal routes have several advantages …