From therapeutic drug monitoring to model‐informed precision dosing for antibiotics
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
Management of sepsis and septic shock in the emergency department
F Gavelli, LM Castello, GC Avanzi - Internal and emergency medicine, 2021 - Springer
Early management of sepsis and septic shock is crucial for patients' prognosis. As the
Emergency Department (ED) is the place where the first medical contact for septic patients is …
Emergency Department (ED) is the place where the first medical contact for septic patients is …
Effect of therapeutic drug monitoring-based dose optimization of piperacillin/tazobactam on sepsis-related organ dysfunction in patients with sepsis: a randomized …
Purpose Insufficient antimicrobial exposure is associated with worse outcomes in sepsis. We
evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves …
evaluated whether therapeutic drug monitoring (TDM)-guided antibiotic therapy improves …
Ventilator-associated pneumonia in patients with SARS-CoV-2-associated acute respiratory distress syndrome requiring ECMO: a retrospective cohort study
CE Luyt, T Sahnoun, M Gautier, P Vidal, S Burrel… - Annals of intensive …, 2020 - Springer
Background The data on incidence, clinical presentation, and outcomes of ventilator-
associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) …
associated pneumonia (VAP) in patients with severe coronavirus disease 2019 (COVID-19) …
[HTML][HTML] Diagnosis and management of infections caused by multidrug-resistant bacteria: guideline endorsed by the Italian Society of Infection and Tropical Diseases …
G Tiseo, G Brigante, DR Giacobbe, AE Maraolo… - International Journal of …, 2022 - Elsevier
Management of patients with infections caused by multidrug-resistant organisms is
challenging and requires a multidisciplinary approach to achieve successful clinical …
challenging and requires a multidisciplinary approach to achieve successful clinical …
Continuous vs intermittent meropenem administration in critically ill patients with sepsis: the MERCY randomized clinical trial
Importance Meropenem is a widely prescribed β-lactam antibiotic. Meropenem exhibits
maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant …
maximum pharmacodynamic efficacy when given by continuous infusion to deliver constant …
Optimizing antimicrobial use: challenges, advances and opportunities
An optimal antimicrobial dose provides enough drug to achieve a clinical response while
minimizing toxicity and development of drug resistance. There can be considerable …
minimizing toxicity and development of drug resistance. There can be considerable …
[HTML][HTML] Model-informed precision dosing: State of the art and future perspectives
Abstract Model-informed precision dosing (MIPD) stands as a significant development in
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
personalized medicine to tailor drug dosing to individual patient characteristics. MIPD moves …
The spectrum of sepsis-associated encephalopathy: a clinical perspective
Sepsis-associated encephalopathy is a severe neurologic syndrome characterized by a
diffuse dysfunction of the brain caused by sepsis. This review provides a concise overview of …
diffuse dysfunction of the brain caused by sepsis. This review provides a concise overview of …
International consensus recommendations for the use of prolonged‐infusion beta‐lactam antibiotics: Endorsed by the American College of Clinical Pharmacy, British …
Intravenous β‐lactam antibiotics remain a cornerstone in the management of bacterial
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …
infections due to their broad spectrum of activity and excellent tolerability. β‐lactams are well …