The 40000-f0ld variation in eukaryote haploid DNA content is unrelated to organismic
complexity or to the numbers of protein-coding genes. In eukaryote microorganisms, as well …

▪ Abstract The MCM proteins are essential replication initiation factors originally identified as
proteins required for minichromosome maintenance in Saccharomyces cerevisiae. The best …

The temporal and spatial progression of DNA replication in interphase nuclei of eukaryotic
cells has been investigated. Application of a recently developed technique for the …

In proliferating cells, DNA synthesis must be performed with extreme precision. We show
that groups of replicons, labeled together as replicon clusters, form stable units of …

DNA replication occurs in microscopically visible complexes at discrete sites (replication
foci) in the nucleus. These foci consist of DNA associated with replication machineries, ie …

We have isolated yeast mutants that are defective in the maintenance of circular
minichromosomes. The minichromosomes are mitotically stable plasmids, each of which …

In mammalian cells, it has been shown that adjacent multiple DNA replicons, termed a
replicon cluster or a replicon domain, are replicated coordinately in a defined temporal order …

According to the current paradigm, replication foci are discrete sites in the interphase
nucleus where assemblies of DNA replication enzymes simultaneously elongate the …

GALAXIES, mapped in two or three dimensions, are not distributed randomly but are
clustered on small scales (< 5 h− 1 Mpc, where h≈ 0.5–1 is Hubble's constant in units of …

Recent studies have indicated that the DNA of the eucaryotic nucleus is organized in the
form of supercoiled loops. We show here that after depleting interphase nuclei of histones …