Aging is a major risk factor for many diseases including metabolic syndrome, cancer,
inflammation, and neurodegeneration. Identifying mechanistic common denominators …

Seasonal and pandemic influenza are the two faces of respiratory infections caused by
influenza viruses in humans. As seasonal influenza occurs on an annual basis, the …

Many oncogenic insults deregulate RNA splicing, often leading to hypersensitivity of tumors
to spliceosome-targeted therapies (STTs). However, the mechanisms by which STTs …

A conserved biological response to double-stranded RNA, known variously as RNA
interference (RNAi) or post-transcriptional gene silencing, mediates resistance to both …

The airway epithelium acts as a frontline defense against respiratory viruses, not only as a
physical barrier and through the mucociliary apparatus but also through its immunological …

Accumulating evidence suggests that endoplasmic reticulum (ER) stress plays a role in the
pathogenesis of diabetes, contributing to pancreatic β-cell loss and insulin resistance …

RNA interference (RNAi) was first recognized in Caenorhabditis elegans as a biological
response to exogenous double-stranded RNA (dsRNA), which induces sequence-specific …

Among the 3 billion base pairs of the human genome, there are∼ 30,000–40,000 protein-
coding genes, but the function of at least half of them remains unknown. A new tool—short …

Protein kinase RNA-activated (PKR) induces immune response by sensing viral double-
stranded RNAs (dsRNAs). However, growing evidence suggests that PKR can also be …

The double-stranded RNA-dependent protein kinase PKR is a critical mediator of the
antiproliferative and antiviral effects exerted by interferons. Not only is PKR an effector …