HSPA8/HSC70 is a molecular chaperone involved in a wide variety of cellular processes. It
plays a crucial role in protein quality control, ensuring the correct folding and re-folding of …

Aging is a complex and inevitable biological process affected by a combination of external
environmental and genetic factors. Humans are currently living longer than ever before …

How the network around ROS protects against oxidative stress and Parkinson's disease
(PD), and how processes at the minutes timescale cause disease and aging after decades …

Parkinson's disease (PD) is the second-most prevalent neurodegenerative disorder,
characterized by the loss of dopaminergic neurons (mDA) in the midbrain. The underlying …

Chaperone-mediated autophagy (CMA) represents a selective form of autophagy involved
in the degradation of specific soluble proteins containing a pentapeptide motif that is …

Brain aging is characterized by a time-dependent decline of tissue integrity and function,
and it is a major risk for neurodegenerative diseases and brain cancer. Chaperone …

Autophagy is a highly conserved process by which long-lived macromolecules, protein
aggregates and dysfunctional/damaged organelles are delivered to lysosomes for …

There is increasing evidence that dysfunction of essential metal (Cu, Zn, Fe, Mn)
homeostasis can lead to the appearance of several NDs. Other neurotoxic environmental …

Biomedical and (neuro) toxicity research on (neuro) degenerative diseases still relies
strongly on animal models. However, the use of laboratory animals is often undesirable for …

Trehalose is a natural dietary molecule that has shown antiaging and neuroprotective effects
in several animal models of neurodegenerative diseases. The role of trehalose in the …