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In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer
M Santos, M Martínez-Fernández, M Duenas… - Cancer …, 2014 - aacrjournals.org
Bladder cancer is a highly prevalent human disease in which retinoblastoma (Rb) pathway
inactivation and epigenetic alterations are common events. However, the connection …
inactivation and epigenetic alterations are common events. However, the connection …
CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status
C Rubio, M Martinez-Fernandez, C Segovia… - Clinical Cancer …, 2019 - aacrjournals.org
Purpose: Bladder cancer is a clinical and social problem due to its high incidence and
recurrence rates. It frequently appears in elderly patients showing other medical …
recurrence rates. It frequently appears in elderly patients showing other medical …
Oh, the mutations you'll acquire! A systematic overview of cutaneous squamous cell carcinoma
S Droll, X Bao - Cellular physiology and biochemistry …, 2021 - pmc.ncbi.nlm.nih.gov
Nearly two million cases of cutaneous squamous cell carcinoma (cSCC) are diagnosed
every year in the United States alone. cSCC is notable for both its prevalence and its …
every year in the United States alone. cSCC is notable for both its prevalence and its …
Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer
I Thurlings, LM Martinez-Lopez, B Westendorp, M Zijp… - Oncogene, 2017 - nature.com
E2F transcription factors are important regulators of the cell cycle, and unrestrained
activation of E2F-dependent transcription is considered to be an important driver of tumor …
activation of E2F-dependent transcription is considered to be an important driver of tumor …
MiR-1258 promotes the apoptosis of cervical cancer cells by regulating the E2F1/P53 signaling pathway
X Peng, Y Zhang, J Gao, C Cai - Experimental and Molecular Pathology, 2020 - Elsevier
Objective Cervical cancer is the most common malignant tumor in gynaecology with high
mortality. MiRNA has been reported to regulate cell biological processes in cervical cancer …
mortality. MiRNA has been reported to regulate cell biological processes in cervical cancer …
A Polycomb-mir200 loop regulates clinical outcome in bladder cancer
M Martínez-Fernández, M Dueñas, A Feber… - …, 2015 - pmc.ncbi.nlm.nih.gov
Bladder cancer (BC) is a highly prevalent disease, ranking fifth in the most common cancers
worldwide. Various miRNAs have recently emerged as potential prognostic biomarkers in …
worldwide. Various miRNAs have recently emerged as potential prognostic biomarkers in …
Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property
Cadmium (Cd) is a toxic heavy metal and one of carcinogens that cause lung cancer.
However, the exact mechanism of Cd carcinogenesis remains unclear. To investigate the …
However, the exact mechanism of Cd carcinogenesis remains unclear. To investigate the …
Akt signaling leads to stem cell activation and promotes tumor development in epidermis
C Segrelles, R García-Escudero, MI Garín… - Stem …, 2014 - academic.oup.com
Hair follicle stem cells (HF-SCs) alternate between periods of quiescence and proliferation,
to finally differentiate into all the cell types that constitute the hair follicle. Also, they have …
to finally differentiate into all the cell types that constitute the hair follicle. Also, they have …
High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration
During oogenesis, hundreds of maternal RNAs are selectively localized to the animal or
vegetal pole, including determinants of somatic and germline fates. Although microarray …
vegetal pole, including determinants of somatic and germline fates. Although microarray …
The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis
C Chapard, D Hohl, M Huber - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
The TRAF-interacting protein (TRAIP) is an E3 ubiquitin ligase required for cell proliferation.
TRAIP mRNA is downregulated in human keratinocytes after inhibition of the …
TRAIP mRNA is downregulated in human keratinocytes after inhibition of the …