In Vivo Disruption of an Rb–E2F–Ezh2 Signaling Loop Causes Bladder Cancer

M Santos, M Martínez-Fernández, M Duenas… - Cancer …, 2014 - aacrjournals.org
Bladder cancer is a highly prevalent human disease in which retinoblastoma (Rb) pathway
inactivation and epigenetic alterations are common events. However, the connection …

CDK4/6 Inhibitor as a Novel Therapeutic Approach for Advanced Bladder Cancer Independently of RB1 Status

C Rubio, M Martinez-Fernandez, C Segovia… - Clinical Cancer …, 2019 - aacrjournals.org
Purpose: Bladder cancer is a clinical and social problem due to its high incidence and
recurrence rates. It frequently appears in elderly patients showing other medical …

Oh, the mutations you'll acquire! A systematic overview of cutaneous squamous cell carcinoma

S Droll, X Bao - Cellular physiology and biochemistry …, 2021 - pmc.ncbi.nlm.nih.gov
Nearly two million cases of cutaneous squamous cell carcinoma (cSCC) are diagnosed
every year in the United States alone. cSCC is notable for both its prevalence and its …

Synergistic functions of E2F7 and E2F8 are critical to suppress stress-induced skin cancer

I Thurlings, LM Martinez-Lopez, B Westendorp, M Zijp… - Oncogene, 2017 - nature.com
E2F transcription factors are important regulators of the cell cycle, and unrestrained
activation of E2F-dependent transcription is considered to be an important driver of tumor …

MiR-1258 promotes the apoptosis of cervical cancer cells by regulating the E2F1/P53 signaling pathway

X Peng, Y Zhang, J Gao, C Cai - Experimental and Molecular Pathology, 2020 - Elsevier
Objective Cervical cancer is the most common malignant tumor in gynaecology with high
mortality. MiRNA has been reported to regulate cell biological processes in cervical cancer …

A Polycomb-mir200 loop regulates clinical outcome in bladder cancer

M Martínez-Fernández, M Dueñas, A Feber… - …, 2015 - pmc.ncbi.nlm.nih.gov
Bladder cancer (BC) is a highly prevalent disease, ranking fifth in the most common cancers
worldwide. Various miRNAs have recently emerged as potential prognostic biomarkers in …

Down-regulation of lncRNA MEG3 promotes chronic low dose cadmium exposure-induced cell transformation and cancer stem cell-like property

HP Lin, M Rea, Z Wang, C Yang - Toxicology and applied pharmacology, 2021 - Elsevier
Cadmium (Cd) is a toxic heavy metal and one of carcinogens that cause lung cancer.
However, the exact mechanism of Cd carcinogenesis remains unclear. To investigate the …

Akt signaling leads to stem cell activation and promotes tumor development in epidermis

C Segrelles, R García-Escudero, MI Garín… - Stem …, 2014 - academic.oup.com
Hair follicle stem cells (HF-SCs) alternate between periods of quiescence and proliferation,
to finally differentiate into all the cell types that constitute the hair follicle. Also, they have …

High-throughput analysis reveals novel maternal germline RNAs crucial for primordial germ cell preservation and proper migration

DA Owens, AM Butler, TH Aguero… - …, 2017 - journals.biologists.com
During oogenesis, hundreds of maternal RNAs are selectively localized to the animal or
vegetal pole, including determinants of somatic and germline fates. Although microarray …

The TRAF-interacting protein (TRAIP) is a novel E2F target with peak expression in mitosis

C Chapard, D Hohl, M Huber - Oncotarget, 2015 - pmc.ncbi.nlm.nih.gov
The TRAF-interacting protein (TRAIP) is an E3 ubiquitin ligase required for cell proliferation.
TRAIP mRNA is downregulated in human keratinocytes after inhibition of the …