In most cases, metastasis, not the primary tumour per se, is the main cause of mortality in
cancer patients. In order to effectively escape the tumour, enter the circulation and establish …

Cell motility is central to tissue homeostasis in health and disease, and there is hardly any
cell in the body that is not motile at a given point in its life cycle. Important physiological …

Blood platelets are critical for hemostasis and thrombosis and play diverse roles during
immune responses. Despite these versatile tasks in mammalian biology, their skills on a …

Tumor metastasis is the primary cause of death of cancer patients. Understanding the
molecular mechanisms underlying tumor metastasis will provide potential drug targets. We …

In addition to their role in providing cellular energy, mitochondria fulfill a key function in
cellular calcium management. The present review provides an integrative view of cellular …

Mounting in vitro, in vivo and clinical evidence suggest an important role for filopodia in
driving cancer cell invasion. Using a high-throughput microscopic-based drug screen, we …

Background The novel sodium-glucose co-transporter 2 inhibitor (SGLT2i) potentially
ameliorates heart failure and reduces cardiac arrhythmia. Cardiac fibrosis plays a pivotal …

Voltage-gated calcium (CaV) channels are ubiquitously expressed in various cell types
throughout the body. In principle, the molecular identity, biophysical profile, and …

Tumour metastasis is the primary cause of death of cancer patients. Development of new
therapeutics preventing tumour metastasis is urgently needed. Migrastatin is a natural …

Since electrical stimulation (ES) can significantly accelerate bone healing, a conductive
scaffold that can deliver ES locally at the defect site is desirable for bone defect therapy …