Alzheimer's disease (AD) is an age-related disease pathologically defined by the deposition
of amyloid plaques and neurofibrillary tangles in the brain parenchyma. Single-cell profiling …

Selective vulnerability of specific brain regions and cell populations is a hallmark of
neurodegenerative disorders. Mechanisms of selective vulnerability involve neuronal …

Alzheimer's disease (AD) is the most common cause of dementia worldwide, but the
molecular and cellular mechanisms underlying cognitive impairment remain poorly …

Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years,
indicating a period of cognitive resilience before the onset of dementia. Here, we report that …

As important immune cells, microglia undergo a series of alterations during aging that
increase the susceptibility to brain dysfunctions. However, the longitudinal characteristics of …

Some individuals are able to maintain their cognitive abilities despite the presence of
significant Alzheimer's Disease (AD) neuropathological changes. This discrepancy between …

Aberrant activity of cyclin-dependent kinase (Cdk5) has been implicated in various
neurodegenerative diseases. This deleterious effect is mediated by pathological cleavage of …

Organismal aging exhibits wide-ranging hallmarks in divergent cell types across tissues,
organs, and systems. The advancement of single-cell technologies and generation of rich …

Individuals who maintain cognitive function despite high levels of Alzheimer's disease (AD)-
associated pathology are said to be 'resilient'to AD. Identifying mechanisms underlying …

Abstract Assay for Transposase Accessible Chromatin by sequencing (ATAC-seq)
accurately depicts the chromatin regulatory state and altered mechanisms guiding gene …