The first organophosphorus nerve agent was discovered accidently during the development
of pesticides, shortly after the first use of chemical weapons (chlorine, phosgene) on the …

Oxime reactivators of acetylcholinesterase are commonly used to treat highly toxic
organophosphate poisoning. They are effective nucleophiles that can restore the catalytic …

Six novel brominated bis-pyridinium oximes were designed and synthesized to increase
their nucleophilicity and reactivation ability of phosphorylated acetylcholinesterase (AChE) …

In this review, the current progress in the research and development of butyrylcholinesterase
(BChE) reactivators is summarised and the advantages or disadvantages of these …

Olesoxime, a cholesterol derivative with an oxime group, possesses the ability to cross the
blood–brain barrier, and has demonstrated excellent safety and tolerability properties in …

Organophosphorus compounds are highly toxic irreversible inhibitors of cholinesterases,
causing the disruption of cholinergic functions. Treatment of poisoning includes causal …

Mono-quaternary pyridinium oximes derived from K-oximes K027, K048 and K203 were
designed, synthesized and evaluated for the reactivation of organophosphate-inhibited …

Seven pyridoxal dioxime quaternary salts (1–7) were synthesized with the aim of studying
their interactions with human acetylcholinesterase (AChE) and butyrylcholinesterase …

(Oksimler), reaktivasyon potansiyeli, geniş etki spektrumu ve kan-beyin bariyerinden
penetrasyon hızı açısından çeşitli sınırlamalara sahiptir. Devam eden çalışmalar yeni …

University of Hradec Kralove Faculty of Science Department of Chemistry Modified
cholinesterase reactivators for enhanced transf Page 1 University of Hradec Kralove Faculty of …