Gene expression involves transcription, translation and the turnover of mRNAs and proteins.
The degree to which protein abundances scale with mRNA levels and the implications in …

As our understanding of the cell interior has grown, we have come to appreciate that most
cellular operations are localized, that is, they occur at discrete and identifiable locations or …

INTRODUCTION Temporally consolidated behaviors such as sleep normally occur in
synchrony with endogenous circadian rhythms and both have been reported to contribute to …

INTRODUCTION RNA sequencing and in situ hybridization have revealed the presence of
an unexpectedly high number of RNA species in neuronal dendrites and axons, and many …

To form synaptic connections and store information, neurons continuously remodel their
proteomes. The impressive length of dendrites and axons imposes logistical challenges to …

Cells adopt highly polarized shapes and form distinct subcellular compartments in many
cases due to the localization of many mRNAs to specific areas, where they are translated …

The transport of mRNAs to distal subcellular compartments is an important component of
spatial gene expression control in neurons. However, the mechanisms that control mRNA …

The importance of subcellular mRNA localization is well established, but the underlying
mechanisms mostly remain an enigma. Early studies suggested that specific mRNA …

A large number of mutations in genes that encode RNA binding proteins cause human
disease. Many of these RNA binding proteins mediate key steps in post-transcriptional …

Spatial regulation of RNA plays a critical role in gene expression regulation and cellular
function. Understanding spatially resolved RNA dynamics and translation is vital for bringing …