Although the discovery of the critical role of α-synuclein (α-syn) in the pathogenesis of
Parkinson's disease (PD) is now twenty-five years old, it still represents a milestone in PD …

Most neurodegenerative diseases are characterized by the intracellular or extracellular
aggregation of misfolded proteins such as amyloid-β and tau in Alzheimer disease, α …

Protein aggregation is the main hallmark of neurodegenerative diseases. Many proteins
found in pathological inclusions are known to undergo liquid-liquid phase separation, a …

Growing evidence suggests an increasing significance for the extent of gastrointestinal tract
(GIT) dysfunction in Parkinson's disease (PD). Most patients suffer from GIT symptoms …

Background Parkinson's disease (PD) is a progressive neurodegenerative disorder
associated with a loss of dopaminergic (DA) neurons. Despite symptomatic therapies, there …

Alpha-synuclein (α-Syn) is a key protein involved in Parkinson's disease (PD) pathology. PD
is characterized by the loss of dopaminergic neuronal cells in the substantia nigra pars …

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by
motor and non-motor symptoms. More than 200 years after its first clinical description, PD …

Many of the motor symptoms of Parkinson disease (PD) can be preceded, sometimes for
several years, by non-motor symptoms that include hyposmia, sleep disorders, depression …

Abstract α-Synuclein (α-Syn) has been extensively studied for its structural and biophysical
properties owing to its pathophysiological role in Parkinson's disease (PD). Lewy bodies …

Neurodegenerative diseases pose a substantial socioeconomic burden on society.
Unfortunately, the aging world population and lack of effective cures foreshadow a negative …