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Antimicrobial resistance in ESKAPE pathogens
Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …
A field guide to eukaryotic transposable elements
Transposable elements (TEs) are mobile DNA sequences that propagate within genomes.
Through diverse invasion strategies, TEs have come to occupy a substantial fraction of …
Through diverse invasion strategies, TEs have come to occupy a substantial fraction of …
Bridge RNAs direct programmable recombination of target and donor DNA
Genomic rearrangements, encompassing mutational changes in the genome such as
insertions, deletions or inversions, are essential for genetic diversity. These rearrangements …
insertions, deletions or inversions, are essential for genetic diversity. These rearrangements …
Structural mechanism of bridge RNA-guided recombination
Insertion sequence (IS) elements are the simplest autonomous transposable elements found
in prokaryotic genomes. We recently discovered that IS110 family elements encode a …
in prokaryotic genomes. We recently discovered that IS110 family elements encode a …
Mobile genetic elements associated with antimicrobial resistance
Strains of bacteria resistant to antibiotics, particularly those that are multiresistant, are an
increasing major health care problem around the world. It is now abundantly clear that both …
increasing major health care problem around the world. It is now abundantly clear that both …
Metallo-β-lactamases in the age of multidrug resistance: from structure and mechanism to evolution, dissemination, and inhibitor design
Antimicrobial resistance is one of the major problems in current practical medicine. The
spread of genes coding for resistance determinants among bacteria challenges the use of …
spread of genes coding for resistance determinants among bacteria challenges the use of …
Diversity, evolution, and classification of the RNA-guided nucleases TnpB and Cas12
The TnpB proteins are transposon-associated RNA-guided nucleases that are among the
most abundant proteins encoded in bacterial and archaeal genomes, but whose functions in …
most abundant proteins encoded in bacterial and archaeal genomes, but whose functions in …
Evolutionary mining and functional characterization of TnpB nucleases identify efficient miniature genome editors
G **ang, Y Li, J Sun, Y Huo, S Cao, Y Cao, Y Guo… - Nature …, 2024 - nature.com
As the evolutionary ancestor of Cas12 nuclease, the transposon (IS200/IS605)-encoded
TnpB proteins act as compact RNA-guided DNA endonucleases. To explore their …
TnpB proteins act as compact RNA-guided DNA endonucleases. To explore their …
Deciphering the transfers of antibiotic resistance genes under antibiotic exposure conditions: driven by functional modules and bacterial community
Q Zhao, W Guo, H Luo, C **ng, H Wang, B Liu, Q Si… - Water Research, 2021 - Elsevier
Antibiotics can exert selective pressures on sludge as well as affect the emergence and
spread of antibiotic resistance genes (ARGs). However, the underlying mechanisms of …
spread of antibiotic resistance genes (ARGs). However, the underlying mechanisms of …
The impact of insertion sequences on bacterial genome plasticity and adaptability
Transposable elements (TE), small mobile genetic elements unable to exist independently
of the host genome, were initially believed to be exclusively deleterious genomic parasites …
of the host genome, were initially believed to be exclusively deleterious genomic parasites …