The mammalian ionotropic glutamate receptor family encodes 18 gene products that
coassemble to form ligand-gated ion channels containing an agonist recognition site, a …

Sigma (σ) receptors, initially described as a subtype of opioid receptors, are now considered
unique receptors. Pharmacological studies have distinguished two types of σ receptors …

Objective Early‐onset epileptic encephalopathies have been associated with de novo
mutations of numerous ion channel genes. We employed techniques of modern translational …

Since the N-methyl-D-aspartate receptor (NMDAR) subunits were cloned less than two
decades ago, a substantial amount of research has been invested into understanding their …

We have compared the potencies of structurally distinct channel blockers at recombinant
NR1/NR2A, NR1/NR2B, NR1/NR2C and NR1/NR2D receptors. The IC50 values varied with …

Glutamate represents a key excitatory neurotransmitter in the central nervous system, and
also modulates the function and viability of endocrine cells in pancreatic islets. In insulin …

Adjuvants are compounds which by themselves have undesirable side-effects or low
potency but in combination with opioids allow a reduction of narcotic dosing for …

Dextromethorphan (3-methoxy-N-methylmorphinan), also known as “DXM” and “the poor
man's PCP,” is a synthetically produced drug that is available in more than 140 over-the …

The molecular events controlling glutamate receptor ion channel gating are complex. The
movement of transmembrane domain M3 within N-methyl-d-aspartate (NMDA) receptor …

Introduction: The NMDA receptor is a ligand-gated ion channel that plays a critical role in
higher level brain processes and has been implicated in a range of neurological and …