Successful approaches for eradication or cure of HIV-1 infection are likely to include
immunological mechanisms, but remarkably little is known about how human immune …

HIV-1 persists in a latent reservoir in resting CD4+ T cells despite antiretroviral therapy
(ART). The reservoir decays slowly over the first 7 years of ART (t 1/2= 44 months). However …

Abstract Purpose of Review In this review, we discuss what persistent viremia has taught us
about the biology of the HIV-1 reservoir during antiretroviral therapy (ART). We will also …

Abstract Non-suppressible HIV-1 viremia (NSV) is defined as persistent low-level viremia on
antiretroviral therapy (ART) without evidence of ART non-adherence or significant drug …

CD4+ T cells with latent HIV-1 infection persist despite treatment with antiretroviral agents
and represent the main barrier to a cure of HIV-1 infection. Pharmacological disruption of …

The latent reservoir for HIV-1 in resting CD4+ T cells persists despite antiretroviral therapy
as a barrier to cure. The antigendriven proliferation of infected cells is a major mechanism of …

Human immunodeficiency virus (HIV) infection induces immunological dysfunction, which
limits the elimination of HIV-infected cells during treated infection. Identifying and targeting …

BACKGROUND HIV-1–infected CD4+ T cells contribute to latent reservoir persistence by
proliferating while avoiding immune recognition. Integration features of intact proviruses in …

HIV-1 integration introduces ectopic transcription factor binding sites into host chromatin. We
postulate that the integrated provirus serves as an ectopic enhancer that recruits additional …

HIV-1 reservoir cells that circulate in peripheral blood during suppressive antiretroviral
therapy (ART) have been well characterized, but little is known about the dissemination of …