The role of iron in brain ageing and neurodegenerative disorders

RJ Ward, FA Zucca, JH Duyn, RR Crichton… - The Lancet …, 2014 - thelancet.com
In the CNS, iron in several proteins is involved in many important processes such as oxygen
transportation, oxidative phosphorylation, myelin production, and the synthesis and …

Quantitative susceptibility map** (QSM): decoding MRI data for a tissue magnetic biomarker

Y Wang, T Liu - Magnetic resonance in medicine, 2015 - Wiley Online Library
In MRI, the main magnetic field polarizes the electron cloud of a molecule, generating a
chemical shift for observer protons within the molecule and a magnetic susceptibility …

[HTML][HTML] Ageing and Parkinson's disease: why is advancing age the biggest risk factor?

A Reeve, E Simcox, D Turnbull - Ageing research reviews, 2014 - Elsevier
As the second most common age related neurodegenerative disease after Alzheimer's
disease, the health, social and economic impact resulting from Parkinson's disease will …

Striking while the iron is hot: Iron metabolism and ferroptosis in neurodegeneration

S Masaldan, AI Bush, D Devos, AS Rolland… - Free Radical Biology …, 2019 - Elsevier
Perturbations in iron homeostasis and iron accumulation feature in several
neurodegenerative disorders including Alzheimer's disease (AD), Parkinson's disease (PD) …

On cell loss and selective vulnerability of neuronal populations in Parkinson's disease

N Giguère, S Burke Nanni, LE Trudeau - Frontiers in neurology, 2018 - frontiersin.org
Significant advances have been made uncovering the factors that render neurons
vulnerable in Parkinson's disease (PD). However, the critical pathogenic events leading to …

Iron neurochemistry in Alzheimer's disease and Parkinson's disease: targets for therapeutics

AA Belaidi, AI Bush - Journal of neurochemistry, 2016 - Wiley Online Library
Brain iron homeostasis is increasingly recognized as a potential target for the development
of drug therapies for aging‐related disorders. Dysregulation of iron metabolism associated …

[HTML][HTML] Quantitative susceptibility map** (QSM) as a means to measure brain iron? A post mortem validation study

C Langkammer, F Schweser, N Krebs, A Deistung… - Neuroimage, 2012 - Elsevier
Quantitative susceptibility map** (QSM) is a novel technique which allows determining the
bulk magnetic susceptibility distribution of tissue in vivo from gradient echo magnetic …

Susceptibility‐weighted imaging and quantitative susceptibility map** in the brain

C Liu, W Li, KA Tong, KW Yeom… - Journal of magnetic …, 2015 - Wiley Online Library
Susceptibility‐weighted imaging (SWI) is a magnetic resonance imaging (MRI) technique
that enhances image contrast by using the susceptibility differences between tissues. It is …

Eriodictyol ameliorates cognitive dysfunction in APP/PS1 mice by inhibiting ferroptosis via vitamin D receptor-mediated Nrf2 activation

L Li, WJ Li, XR Zheng, QL Liu, Q Du, YJ Lai, SQ Liu - Molecular Medicine, 2022 - Springer
Background Alzheimer's disease (AD) is the most common type of neurodegenerative
disease in the contemporary era, and it is still clinically incurable. Eriodictyol, a natural …

Overview of quantitative susceptibility map**

A Deistung, F Schweser… - NMR in …, 2017 - Wiley Online Library
Magnetic susceptibility describes the magnetizability of a material to an applied magnetic
field and represents an important parameter in the field of MRI. With the recently introduced …