Breaking boundaries: the advancements in transdermal delivery of antibiotics

A Zaid Alkilani, R Hamed, B Musleh, Z Sharaire - Drug Delivery, 2024 - Taylor & Francis
Transdermal drug delivery systems (TDDS) for antibiotics have seen significant advances in
recent years that aimed to improve the efficacy and safety of these drugs. TDDS offer many …

Exploring the use of niosomes in cosmetics for efficient dermal drug delivery

R Abu-Huwaij, A Alkarawi, D Salman… - Pharmaceutical …, 2023 - Taylor & Francis
Dermal drug delivery has emerged as a promising alternative to traditional methods of drug
administration due to its non-invasive nature and ease of use. However, the stratum …

Transdermal Delivery System of Doxycycline-Loaded Niosomal Gels: Toward Enhancing Doxycycline Stability

A Zaid Alkilani, Z Sharaire, R Hamed, HA Basheer - ACS omega, 2024 - ACS Publications
Doxycycline (DOX) is an antimicrobial agent that is susceptible to photosensitivity and
thermal degradation. It addition, it causes gastrointestinal side effects when taken orally …

Preparation and characterization of patch loaded with clarithromycin nanovesicles for transdermal drug delivery

A Zaid Alkilani, B Musleh, R Hamed… - Journal of Functional …, 2023 - mdpi.com
Clarithromycin (CLR), categorized as a Biopharmaceutical Classification System class II
drug, has several gastrointestinal tract side effects and an extremely unpalatable bitter taste …

Qbd-based approach to optimize niosomal gel of levosulpiride for transdermal drug delivery

AS Alnaim, H Shah, AB Nair, V Mewada, S Patel… - Gels, 2023 - mdpi.com
Poor aqueous solubility besides extensive hepatic first effect significantly decreases the oral
absorption of levosulpiride, which in turn minimizes its therapeutic effectiveness. Niosomes …

Development and evaluation of an innovative approach using niosomes based polymeric microneedles to deliver dual antioxidant drugs

A Zaid Alkilani, H Abo-Zour, HA Basheer, H Abu-Zour… - Polymers, 2023 - mdpi.com
Ascorbic acid (AA) and caffeine (CAFF) work to protect cells from ultraviolet (UV) radiation
and slow down the photoaging process of the skin. However, cosmetic application of AA and …

[HTML][HTML] Characterisation of niosome nanoparticles prepared by microfluidic mixing for drug delivery

MA Obeid, I Khadra, AAA Aljabali, H Amawi… - International journal of …, 2022 - Elsevier
Lipid nanoparticles have gained much attention due to their potential as drug delivery
systems. They are safe, effective, and be targeted to particular tissues to deliver their …

Composition, preparation methods, and applications of nanoniosomes as codelivery systems: a review of emerging therapies with emphasis on cancer

M Roostaee, A Derakhshani, H Mirhosseini… - Nanoscale, 2024 - pubs.rsc.org
Nanoniosome-based drug codelivery systems have become popular therapeutic
instruments, demonstrating tremendous promise in cancer therapy, infection treatment, and …

Microneedles mediated-dermal delivery of Vitamin C: Formulation, characterization, cytotoxicity, and enhancement of stability

R Hamed, AD AbuKwiak, R Aburayya, AZ Alkilani… - Heliyon, 2024 - cell.com
Abstract Vitamin C (VIT C) is an antioxidant that prevents skin aging. Although dermal
delivery is one of the most effective routes to transport VIT C to the skin, the impact of this …

Olive oil and flaxseed oil incorporating niosomes for enhanced in vivo anti-diabetic efficacy of canagliflozin

G Saad, GM El Maghraby, AA Sultan - Drug Development and …, 2024 - Taylor & Francis
Background Canagliflozin (CFZ) is broadly implicated for the management of type 2
diabetes mellitus. Unfortunately, it has low oral bioavailability due to poor solubility behavior …