Immunology of Mycobacterium tuberculosis Infections

JK Sia, J Rengarajan - Microbiology spectrum, 2019 - Am Soc Microbiol
Tuberculosis (TB) is a serious global public health challenge that results in significant
morbidity and mortality worldwide. TB is caused by infection with the bacilli Mycobacterium …

The immune response in tuberculosis

A O'Garra, PS Redford, FW McNab… - Annual review of …, 2013 - annualreviews.org
There are 9 million cases of active tuberculosis reported annually; however, an estimated
one-third of the world's population is infected with Mycobacterium tuberculosis and remains …

Lipid presentation by the protein C receptor links coagulation with autoimmunity

N Müller-Calleja, A Hollerbach, J Royce, S Ritter… - Science, 2021 - science.org
INTRODUCTION Antiphospholipid antibodies (aPLs) transiently appear in infectious
diseases but can persist in primary antiphospholipid syndrome (APS) or in association with …

Siderophore-based iron acquisition and pathogen control

M Miethke, MA Marahiel - Microbiology and molecular biology …, 2007 - Am Soc Microbiol
High-affinity iron acquisition is mediated by siderophore-dependent pathways in the majority
of pathogenic and nonpathogenic bacteria and fungi. Considerable progress has been …

Strategies for innovation in multicomponent reaction design

B Ganem - Accounts of chemical research, 2009 - ACS Publications
By generating structural complexity in a single step from three or more reactants,
multicomponent reactions (MCRs) make it possible to synthesize target compounds with …

The emerging field of lipidomics

MR Wenk - Nature reviews Drug discovery, 2005 - nature.com
The crucial role of lipids in cell, tissue and organ physiology is demonstrated by a large
number of genetic studies and by many human diseases that involve the disruption of lipid …

Pathogenesis, Immunology, and Diagnosis of Latent Mycobacterium tuberculosis Infection

S Ahmad - Journal of Immunology Research, 2011 - Wiley Online Library
Phagocytosis of tubercle bacilli by antigen‐presenting cells in human lung alveoli initiates a
complex infection process by Mycobacterium tuberculosis and a potentially protective …

The thick waxy coat of mycobacteria, a protective layer against antibiotics and the host's immune system

SM Batt, DE Minnikin, GS Besra - Biochemical Journal, 2020 - portlandpress.com
Tuberculosis, caused by the pathogenic bacterium Mycobacterium tuberculosis (Mtb), is the
leading cause of death from an infectious disease, with a mortality rate of over a million …

CD1: antigen presentation and T cell function

M Brigl, MB Brenner - Annu. Rev. Immunol., 2004 - annualreviews.org
▪ Abstract This review summarizes the major features of CD1 genes and proteins, the
patterns of intracellular trafficking of CD1 molecules, and how they sample different …

Who puts the tubercle in tuberculosis?

DG Russell - Nature Reviews Microbiology, 2007 - nature.com
Tuberculosis (TB), an illness that mainly affects the respiratory system, is one of the world's
most pernicious diseases. TB currently infects one-third of the world's population and kills …